Ronald G. Crystal, M.D.

Pulmonary Disease Medicine


Recent Publications

Leopold PL, Wendland RL, Vincent T, Crystal RG. Neutralized adenovirus-immune complexes can mediate effective gene transfer via a Fc receptor-dependent infection pathway. J Virol 2006; 80:10237-47


Carolan BJ, Heguy A, Harvey B-G, Leopold PL, Ferris B, Crystal RG. Upregulation of expression of the ubiquitin carboxyl terminal hydrolase L 1 gene in human airway epithelium of cigarette smokers. Ca Res 2006; 66:10729-10740


Worgall S, Crystal RG. Gene Therapy. In: Lanza R, Langer R, Vacanti J, eds. Principles of Tissue Engineering, Third Edition. Elsevier / Academic Press, New York, 2007: 471-492.


Sondhi D, Hackett NR, Peterson DA, Stratton J, Baad M, Travis KM, Wilson JM, Crystal RG. Enhanced performance and survival of the CLN2 knockout mouse model of late infantile neuronal ceroid lipofuscinosis following intracranial delivery of a rhesus macaque-derived adeno-associated virus (AAVrh.10) vector expressing the CLN2 cDNA. Mol Ther 2007; 15:481-491


Strulovici Y, Leopold PL, O#146;Connor TP, Pergolizzi RG, Crystal RG. Human embryonic stem cells and gene therapy. Mol Ther 2007; 15:850-866.


Gelbman BG, Heguy A , O#146;Connor TP, Zabner J, Crystal, RG. Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis Respir Res 2007; 8:10


Heguy A, Harvey BG, Leopold PL, Dolgalev I, Raman T, Crystal RG. Responses of the human airway epithelium transcriptome to in vivo injury. Physiol Genomics 2007; 29:139-148.


Dyke JP, Voss HU, Sondhi D, Hackett NR, Worgall S, Heier LA, Kosofsky BE, Ulu─č AZ, Shungu DC, Mao X, Crystal RG, Ballon D. Assessing disease severity in late infantile neuronal ceroid lipofuscinosis using quantitative magnetic resonance diffusion-weighted imaging. Am J Neruro Res 2007; 28:1232-1236.


Worgall S, Kekatpure MV, Heier L, Ballon D, Dyke JP, Shungu D, Mao X, Kosofsky B, Kaplitt MG, Souweidane MM, Sondhi D, Hackett NR, Hollmann C, Crystal RG. Neurological deterioration in late infantile neuronal ceroid lipofuscinosis. Neurology 2007; 69: 521-535.


Leopold PL, Crystal RG. Intracellular trafficking of adenovirus: Many means to many ends. Adv Drug Deliv Rev 2007; 59:810-821.

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