Publications
Cai J, Yuan H, Weng C, Tan C, Imperato-McGinley J and Zhu YS: Androgens stimulate human aortic endothelial cell proliferation through an androgen receptor-VEGF/cyclin A mediated mechanism. Am J Physiol Heart Circ Physiol, 300(4):H1210-1221, 2011
Cai LQ, Cai J, Wu W and Zhu YS: 17α-estradiol and genistein inhibit a high-fat diet induced prostate gene expression and prostate growth in the rat. J Urology, 186 (40):1489-1496, 2011
Kang H, Imperato-McGinley J, Zhu YS, Cai LQ, Cordero J, Schlegel P, Palermo G and Rosenvaks R: The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation. Fertil Steril, 95(6):2125.e5-8, 2011
Qiao Y, Wang L, Cai LQ, Tan C, Imperato-McGinley J and Zhu YS: Inhibition of aberrant androgen receptor induction of prostate specific antigen gene expression, cell proliferation and tumor growth by 17α-estradiol in prostate cancer. J Urology, 185:305-314, 2011
Zhang N, Zhang HW, Xia L, Zheng Y, Yu Y, Zhu YS, Chen GQ, Di W: NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1 alpha protein in human ovarian cancer cells. Cancer Letters, 278(2):139-144, 2009
Zhu YS and Imperato-McGinley J: Disorders in male sexual differentiation: molecular genetics, gender identity, and cognition, in Hormones, Brain and Behavior. Pfaff DW, Arnold AP, Etgen AM, Fahrbach SE and Rubin RT (eds), 2nd ed, Vol 5, Academic Press, San Diego, CA. pp2787-2824, 2009
Zhu YS and Imperato-McGinley JL: 5α-Reductase isozymes and androgen actions in the prostate. Annals of New York Academy of Sciences, 1155:43-56, 2009
Zhu YS and Imperato-McGinley J: Genetic defects of male sexual differentiation, in Hormone/Behavior Relations of Clinical Importance. Rubin RT and Pfaff DW (eds), Academic Press, Orlando, Florida, pp743-780, 2009
Tan C, Cai LQ, Wu W, Qiao Y, Julianne Imperato-McGinley, Chen GQ, and Zhu YS: NSC606985, A novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells. Cancer Chemotherapy and Pharmacology, 63(2):303-312, 2009 (Epub March 29, 2008)
Zhu YS and Imperato-McGinley J: Male sexual differentiation disorder and 5α-reductase-2 deficiency. Journal of Global Library of Women's Medicine (ISSN: 1756-2228) 2008; DOI 10.3843/GLOWM.10350, (http://www.glowm.com/index.html?p=glowm.cml/section_view&articleid=349#sectionView)
Qiao Y, Zhang Z-k, Cai LQ, Tan C, Julianne L. Imperato-McGinley and Zhu YS: 17alpha-Estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals. Prostate, 67(16):1719-1728, 2007
Butler T, Pan H, Imperato-McGinley J, Voyer D, Cunningham-Bussel AC, Cordero JJ, Zhu YS, Silbersweig D, Stern E: A network approach to fMRI condition-dependent cognitive activation studies as applied to understanding sex differences. Clinical Neuroscience Research, 6(6):391-398, 2007
Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ: Subcellular proteome analysis of camptothecin analog NSC606985-treated acute myeloid leukemic cells. J Proteome Res. 6(9):3808-18, 2007
Butler T, Imperato-McGinley J, Pan H, Voyer D, Cunningham-Bussel AC, Chang L, Zhu YS, Cordero J, Stern E, Silbersweig D. Sex specificity of ventral anterior cingulate cortex suppression during a cognitive test. Human Brain Mapping. 28(11):1206-12, 2007
Liu W, Zhu YS, Guo M, Yu Y, Chen GQ: Therapeutic efficacy of NSC606985, a novel camptothecin analog, in a mouse model of acute promyelocytic leukemia. Leuk Res. 31(11):1565-1574, 2007
Huang Y, Duan QW, Zhu YS Duan YW: In vivo antitumor activity of ZYD88, a Chinese herbal medicine in animal models with S180 sarcoma and Ehrlich tumor. Journal of the Society for Integrative Oncology. 5(2):45-49, 2007
Cohen JK, Cai LQ, Zhu YS and La Perle KM: Pancreaticoduodenal arterial rupture and hemoabdomen in ACI/SegHsd rats with polyarteritis nodosa. Comparative Medicine, 57(4):370-376, 2007
Duan YW, Huang Y, Cai LQ, Duan QW and Zhu YS: The anti-tumor and anti-metastatic effect of a Chinese herbal medicine, ZYD88, in an animal model with the metastatic Lewis lung carcinoma. Oncol Report, 17(6):1391-1397, 2007
Butler T, Pan H, Imperato-McGinley J, Voyer D, Cunningham-Bussel AC, Cordero JJ, Zhu YS, Silbersweig D, Stern E: A network approach to fMRI condition-dependent cognitive activation studies as applied to understanding sex differences. Clinical Neuroscience Research, 6(6):391-398, 2007
Cai LQ, Imperato-McGinley J and Zhu YS: Regulation of prostate 5alpha-reductase isozyme gene expression and prostate weight by dietary fat and caloric intake in the rat. Prostate,66(7):738-748, 2006
Sobel V, Schwartz B, Zhu YS, Cordero J, Imperato-McGinley J: Bone mineral density in the complete androgen insensitivity and 5alpha-reductase-2 deficiency syndromes: evidence for a direct effect of T, but not DHT, on bone strength. J.Clin. Endocrinol. Metab. 91(8):3017-3023, 2006
Butler T, Imperato-McGinley J, Pan H, Voyer D, Cordero J, Zhu YS, Stern E, Silbersweig D: Sex differences in mental rotation: Top down versus bottom up processing. Neuroimage, 32(1):445-56, 2006
Zhu YS, Cai LQ, Huang Y, Fish J, Wang L, Zhang ZK and Imperato-McGinley J: Receptor isoform and ligand specific modulation of DHT-induced PSA gene expression and prostate tumor cell growth by estrogens. J. Androl., 26:500-508, 2005.[Editorial Commentary: Dehm, SM, Tindall DJ: J Androl. 26:509-510, 2005]
Song M-G, Gao S-M, Du K-M, Xu M, Yu Y, Wang Q, Chen Z, Zhu YS and Chen G-Q: NSC606985, A camptothecine analog, induces leukemic cell apoptosis through protein kinase Cd-dependent mechanisms. Blood, 105:3714-3721, 2005.
Zhu YS: Molecular basis of steroid action in the prostate. Cellscience Reviews. 1(4):27-55, 2005 (http://www.cellscience.com/journal/journalindex.asp).
Yan H, Wu YL, Jiang Y, Huang Y, Chen Z, Zhu YS, Zhao Q, Chen GQ: Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica, 90:1607-1616, 2005
Zhu YS and Sung GF: 5alpha-reductase isozymes in the prostate. J. Med. Sci., 25(1):1-11, 2005.
Zhu YS and Imperato-McGinley J: Pseudohermaphroditism, male, due to 5alpha-reductase-2 deficiency. In: Encyclopedia of Endocrine Diseases, vol. 4, Martinii L et al (eds), Elsevier Inc. San Diego, CA, p131-135, 2004.
Lee J, Zhu YS, Cordero JJ, You X, Cai LQ, Labor L and Imperato-McGinley J: Long-term growth hormone therapy in adulthood results in significant linear growth in siblings with a PROP1 gene mutation. J.Clin. Endocrinol. Metab.,89:4850 4856, 2004.
Sobel V, Zhu YS and Imperato-McGinley J: Fetal hormones and sexual differentiation. Obstet. Gynecol. Clin. N. Am., 31:837-856, 2004
Zhu YS and Imperato-McGinley J: Androgen Insensitivity Syndrome. In: Encyclopedia of Endocrine Diseases, vol. 1, Martinii L et al (eds), Elsevier Inc. San Diego, CA, p214-220, 2004.
Zhu YS, Huang Y, Cai LQ, Zhu J, Duan Y, Duan Q, Imperato-McGinley J: A Chinese medicinal herbal formula, ZYD88 inhibited cell growth and promoted cell apoptosis in prostatic tumor cells. Oncology Reports, 10(5):1633-1639, 2003.
Zhu YS, Cordero JJ, Can S, Cai, LQ, Herrera C, DeFillo-Ricart M and Imperato-McGinley J: Mutations in CYP11B1 gene: phenotype-genotype correlations. Am J Med Genet, 122A(3):193-200, 2003.
Zhu YS, Cai LQ, You X, Cordero JJ, Huang Y and Imperato-McGinley J: Androgen-induced of PSA gene expression is mediated via DHT in LNCaP cells. J. Androl., 24(5):681-687, 2003.
Huang Y, Du, KM, Xue ZH, Yan H, Li D, Liu W, Chen Z, Zhao Q, Tong JH, Zhu YS and Chen GQ: Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1alpha. Leukemia, 17:2065-2073, 2003
Zhu YS, Cai LQ, Cordero JJ, Canovatchel WJ, Katz MD and Imperato-McGinley J: A novel mutation in the CAG triplet region of exon 1 of androgen receptor gene causes complete androgen insensitivity syndrome in a large kindred. J. Clin. Endocrinol. Metab., 84:1590 1594, 1999.
Zhu YS, Dellovade TL and Pfaff DW: Interactions between hormonal and environmental signals on hypothalamic neurons: Molecular mechanisms signaling environmental events. Trends Endocrinol. Metab. 8:111-115, 1997
Katz MD, Kligman I, Cai LQ, Zhu YS, Fratianni CM, Neal G, Rosenwaks Z and Imperato-McGinley J: Paternity by intrauterine insemination with sperm from a man with 5alpha-reductase-2 deficiency. N. Engl. J. Med., 336:994-997, 1997.
Zhu YS, Yen PM, Chin WW and Pfaff DW: Estrogen and thyroid hormone interaction on regulation of gene expression. Proc. Natl. Acad. Sci. USA, 93:12587-12592, 1996.
Dellovade TL, Zhu YS, Krey L and Pfaff DW: Thyroid hormone and estrogen interact to regulate behavior. Proc. Natl. Acad. Sci. USA, 93:12581-12586, 1996
Zhu YS, Branch AD, Robertson HD and Inturrisi CE: Cloning and characterization of the hamster proenkephalin gene. DNA Cell Biol., 13:25-35, 1994
Zhu YS, Brodsky M, Franklin SO, Huang TH. and Inturrisi CE: Metrazole induces the sequential activation of c-fos, proenkephalin and tyrosine hydroxylase gene expression in the rat adrenal: Modulation by glucocorticoid and adrenocorticotropic hormone. Mol. Pharmacol., 44:328-336, 1993.
Zhu YS and Szeto HH: Morphine-induced tachycardia in fetal lambs: a bell-shaped dose-response curve, J. Pharmacol. Exp. Ther., 249:78-82, 1989.
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