Ype P. de Jong, M.D., Ph.D.

Gastroenterology

Publications

1. Simpson SJ, Shah S, Comiskey M, de Jong YP, Wang B, Mizoguchi E, Bhan AK, Terhorst C. T cellmediated

pathology in two models of experimental colitis depends predominantly on the interleukin

12/Stat-4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 1998;

187(8): 1225-34.

 

2. Levelt CN, de Jong YP, Mizoguchi E, O'Farrelly C, Bhan AK, Tonegawa S, Terhorst C, Simpson SJ.

High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal

CD8αα and CD8αβ T lymphocytes. Proc Natl Acad Sci USA 1999; 96(10): 5628-33.

 

3. de Jong YP, M Comiskey, SL Kalled, E Mizoguchi, AK Bhan, Terhorst C. Chronic experimental colitis is

dependent on the CD40-CD154 pathway and can be attenuated by anti-CD154 administration.

Gastroenterology 2000 Sep; 119(3):715-23.

 

4. de Jong YP, Abadia-Molina AC, Satoskar AR, Clarke K, Rietdijk ST, Faubion WA, ten Hove T, Al Sahli

M, Mizoguchi E, Metz CN, Michetti P, van Deventer SJ, David JR, Bhan AK, Terhorst C. Chronic colitis

is dependent on the cytokine MIF. Nat Immunol 2001 Nov; 2(11): 1061-6.

 

5. de Jong YP, Rietdijk ST, Abadia-Molina AC, Faubion WA, Clarke K, Delaney T, Mizoguchi E, Guiterrez-

Ramos JC, Bhan AK, Coyle AJ, Terhorst C. Blocking ICOS in the absence of CD28 impairs T helper 1

and CD25 regulatory T cells in murine colitis. Int Immunol 2004 Feb 16(2):205-213.

 

6. Faubion WA, de Jong YP, Abadia-Molina AC, Clarke K, Wang B, Mizoguchi E, Simpson SJ, Bhan AK,

Terhorst C. Colitis is associated with thymic destruction attenuating CD4 CD25 regulatory T cells in

the periphery. Gastroenterology. 2004; 126(7): 1759-70.

 

7. Ploss A, Evans MJ, Gaysinskaya VA, Panis M, You H, de Jong YP, Rice CM. Human occludin is a

hepatitis c virus entry factor required for infection of mouse cells. Nature, 2009;457(7231):882-6. NIHMS

102188

 

8. Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di

Santo JP et al. Humanized mice for modeling human infectious disease: challenges, progress, and

outlook. Cell Host Microbe, 2009 Jul 23;6(1):5-9. Review.

 

9. de Jong BC, Antonio M, Awine T, Ogungbemi K, de Jong YP, Gagneux S, DeRiemer K, Rastogi N,

Borgdorff M, Hill PC, Adegbola RA. Use of spoligotyping and large-sequence polymorphisms to study

the population structure of the Mycobacterium tuberculosis complex in a cohort study of consecutive

smear positive tuberculosis cases in the Gambia. J Clin Micro 2009; 47(4): 994-1001. PMC2668362

 

10. de Jong YP, Rice CM, Ploss A. New horizons for studying human hepatotropic infections. J Clin Invest. 2010 Mar 1;120(3):650-3. Commentary.

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