W. Beau Mitchell, M.D.

Pediatric Hematology-Oncology



  1. Mitchell WB, Li J, Murcia M, Valentin N, Newman PJ, Coller BS. Mapping early conformational changes in aIIb and b3 during biogenesis reveals a potential mechanism for aIIbb3 adopting its bent conformation. Blood, 2007 May 1:109(9):3725-3732.
  2. Peretz H, Rosenberg N, Landau M, Usher S, Nelson EJ, Mor-Cohen R, French DL, Mitchell WB, Nair SC, Chandy M, Coller BS, Srivastava A, Seligsohn U. Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3). Hum Mutat. 2006, Feb 3;27(4):359-369.
  3. Mitchell WB, Li J, French DL, Coller BS. aIIbb3 biogenesis is controlled by engagement of aIIb in the calnexin cycle via the N15-linked glycan. Blood, 2006 April 1:107(7):2713-2719.
  4. Nelson EJ, Li J, Mitchell WB, Chandy M, Srivastava A, Coller BS. Three novel beta-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi. J Thromb Haemost. 2005 Dec;3(12):2773-83.
  5. Andrea Artoni, JiHong Li, Beau Mitchell, Jian Ruan, Junichi Takagi, Tim Springer, Deborah L. French, Barry S. Coller. Integrin b3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin aIIbb3 activation. Proc Natl Acad Sci. 2004 Sep 7:101(36):13114-13120
  6. Deborah L. French, Steven Fruchtman, W. Beau Mitchell, Barry S. Coller. Hava Peretz Evidence for Megakaryocyte Engraftment Following Reduced Intensity Conditioning. Exp Hemat. 2004;32:877-80.
  7. WB Mitchell, J Li, F Singh, J Ruan, AD Michelson, J Bussel, BS Coller, DL French. Two novel mutations in the aIIb calcium-binding domains identify hydrophobic regions essential for aIIbb3 biogenesis. Blood, 2003 March 15;101(6):2268-2277.
  8. S Nair, J Li, WB Mitchell, D Mohanty, BS Coller, DL French. Two new beta3 integrin mutations in Indian patients with Glanzmann thrombasthenia: localization of mutations affecting cysteine residues in integrin beta3. Thromb Haemost. 2002 Sep;88(3):503-9.
  9. B Gordon, B Mitchell, K Mohtadi, E Roth, Y Tseng, F Turk. Lesions of Non-Visual Inputs Affect Plasticity, Norepinephrine Content and Acetylcholine Content of Visual Cortex. Journal Of Neurophysiology 1990, 64:1851-60.


  1. W. Beau Mitchell and James Bussel. IVIG in Hematologic Disorders, In: Alan H Lazarus and John W Semple, eds. Immunoglobulin Therapy. Bethesda, MD: AABB Press; 2010
  2. Barry S. Coller, W. Beau Mitchell, and Deborah L. French. Hereditary Qualitative Platelet Disorders. In: E. Beutler, Marshall Lichtman, Barry Coller , Thomas Kipps, Uri Seligsohn, eds. William’s Hematology; 7th edition. New York, NY: McGraw-Hill; 2006
  3. WB Mitchell and DL French, Glanzmann thrombasthenia in: The NORD Guide to Rare Disorders. Lippincott, Williams & Wilkins. Philadelphia, PA; 2003:pp 383-384

Back to topBack To Top