Wayne Tam, M.D., Ph.D.

Anatomic Pathology



1. Tam, W.**,Ben-Yehuda, D., Hayward, W.S. bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its non-coding RNA. Mol. Cell. Biol. 17:1490-1502, 1997..
2. Tam, W.**Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA. Gene 274:157-167, 2001.
3. Tam, W.**, Hughes, S., Hayward, W., Besmer, P. Avian bic, a gene isolated from a common retroviral site in avian-leukosis-virus-induced lymphomas and encoding a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis. J. Virol. 76: 4275-4286, 2002.
4. Eis, P.S*., Tam, W.*, Sun, L., Chadburn, A., Li, Z., Gomez, M., Lund, E., and Dahlberg, J.E. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. USA102(10):3627-32, 2005. *Co-first author.
5. Cattoretti, G*., Pasqualucci, L*., Ballon, G., Tam, W., Nandual, S.V., Shen. Q., Mo, T., Murty, V.V., and Dalla-Favera, R.   Deregulated BCL-6 expression recapitulates the pathogenesis of human diffuse large B-cell lymphomas in mice. Cancer Cell 7(5):445-55, 2005. *Co-First Author
6. Tam, W.** and Dahlberg, J.E. MiR-155/BIC as an oncogeneic miRNA. Genes Chromosomes Cancer 45:211-212, 2006.
7. Tam, W.**, Gomez, M., Chadburn, A., Lee, J.W., Chan, W.C., and Knowles, D.M. Mutatoinal analysis of PRDM1 indicates a tumor suppressor role in diffuse large B-cell lymphomas. Blood 107(10):4090-4100, 2006 (epub on January 19, 2006)
     ***Article featured in Commentary
8. Tam, W.**, Gomez, M.F., Houldsworth, J., Chadburn, A. and Knowles, D.M.  Lack of A563G (I188V) missense mutation in diffuse large B-cell lymphomas. Genes Chromosomes Cancer 46(4):416-418, 2007.
9. Cheung, K., Tam, W., Chuang E. and Osborne, M.P. A collision tumor consisting of invasive ductal carcinoma and chronic lymphocytic leukemia in breast. The Breast Journal 13(4): 413-417, 2007.
10. Landgraf, et al (multiple authors), Tam, W., Borkhardt, A., Sander, C., Zavolam, M. and Tuschl T. A mammilian microRNA Expression Atlas based on small RNA library sequencing. Cell 129:1401-1414, 2007.
11. Tam, W. **, Gomez, M., and Kui, N. Significance of PRDM1beta expression as a prognostic marker in diffuse large B-cell lymphomas. Blood 111(4):2488-2489, 2008.
12. Wagner, P.L., Tam, W. , Lau, P.Y., Port, J.L., Paul, S., Altorki, N.K., and Lee, P.C. Primary     esophageal   large T Cell lymphoma mimicking esophageal carcinoma: A case report and literature review. The Journal of Thoracic and Cardiovascular Surgery 135 (4):957-958, 2008.
13. Nie, K., Gomez, M., Landgraf, P., Garcia, J.F., Liu, Y.,Tan, LHC,Chadburn, A., Tuschl, T., Knowles, D.M., and Tam, W**. MicroRNA-mediated translational repression of PRDM1 in Hodgkin/Reed-Sternberg cells - a potential pathogenetic lesion in Hodgkin lymphoma. Am J Path 173 (1):242-52, 2008.
14. Zhang, T., Kui, N., and Tam, W**. BIC/microRNA-155 is processed efficiently in Burkitt lymphomas. Leukemia 22:1795-1797, 2008.
15. Mavrakis, K.J., Zhu, H., Silva, R.L.A., Mills, J., Teruya-Feldstein, J., Lowe, S.W., Tam, W., Pelletier, J., and Wendel., H.G. Tumorigenic activity and therapeutic inhibition of Rheb GTPase  Genes & Dev 22:2178-2188, 2008.
16. Chadburn, A., Hyjek, E.M., Tam, W., Liu, Y.F., Rengifo, T., Cesarman, E. and Knowles, D.M.   Immunophenotypic analysis of the Kaposi Sarcoma Herpesvirus (KSHV;HHV-8) infected B cells in HIV-positive multicentric Castleman disease (MCD). Histopathology, 53(5):513-524, 2008.
17. Iqbal, J.*, Kucuk, C.*, deLeeuw, R.J., Srivastava, G., Tam, W., Geng, H., Klinkebiel,, D., Christman, J., Patel, K., Cao, K., Shen, L., Dybkaer,K., Tsui, I., Ali,H.H., Shimizu, N., Au, W.Y., Lam, W.L., and Chan, W.C.  Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia, 2009, in press *co-first authors
18. Nie, K., Zhang T., Allawi, H. Gomez, M., Liu, Y., Chadburn, A., Wang, Y.L. Knowles, D.M., and Tam, W**. Down-regulation of PRDM1/Blimp-1 in diffuse large B-cell lymphomas: Potential role of microRNA let-7 (under review by Hematologica)
19. Fraser, C.., Zhang, T., Gomez, M., Mathew, S., Furman, R., Orazi, A. and Tam, W**. Clonal transformation of   chronic lymphocytic leukmemia/small lymphocytic lymphoma to interdigitating cell sarcoma (under review by Am J Path)
1. Tam, W. ** The emergent role of microRNAs in molecular diagnostics of cancer. Journal of Molecular Diagnostics, 10(5): 411-414, 2008 [Invited commentary]
2. Tam, W. **    MicroRNAs and hematopoietic malignancies: Pathogenesis, diagnosis and prognosis. Expert Reviews of Molecular Diagnostics, 2009, in preparation [Invited review]
1. Tam, W.** MicroRNAs: tiny but not trivial.   Current Genomics, 5(3):191-205, 2004.
2 . Zhang, W., Dahlberg, J.E., and Tam, W.** MicroRNAs in Tumorigenesis: A Primer. Am J Path 171(3):728-738, 2007.
** Corresponding author
1. Tam, W., Dalla-Favera, R. Protooncogenes and tumor suppressor genes in hematopoietic malignancies. In: Neoplastic Hematopathology (2nd), Knowles, D.M. (ed) W.B. Sauders (publ), 329-363, 2000.
2. Chiu, A., Tam, W., Cines, D. and Bussell, J.B. Immune thrombocytopenic purpura: pathophysiology in patients with persistent problems. In: Postgraduate Hematology (5th), S. Lewis , I. Avivi , T. Tuddenham, D. Catovsky, A. A.V. Hoffbrand (ed.) Blackwell Science (publ), 937-944, 2005.
Cloning and characterization of bic, a novel myc collaborator in lymphomagenesis and leukemogenesis. Cornell University, New York.

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