Ralph L. Nachman, M.D.

Medical Oncology


Selected peer-reviewed publications (in chronological order).

(Selected  from approximately 150 peer-reviewed publications)


1.   Nachman, R.L., Hubbard, A., and Ferris B. Iodination of the human platelet membrane: Studies of the major surface glycoprotein. J. Biol. Chem. 248:2928, 1973.


2.   Jaffe, E.A., Nachman, R.L., Becker, C., and Minick, C.R. Studies on cultured human endothelial cells derived from umbilical cord veins. J. Clin. Invest. 52:2745, 1973.


3.   Jaffe, E.A., Hoyer, L., and Nachman, R.L. Synthesis of AHF antigens by cultured human endothelial cells. J. Clin. Invest. 52:2757, 1973.


4.   Nachman, R.L. and Ferris, B. Binding of adenosine diphosphate by isolated membranes from human platelets. J. Biol. Chem. 249:704, 1974.


5.   Jaffe, E., Hoyer, L., and Nachman, R.L. Synthesis of von Willebrand factor by cultured human endothelial cells. Proc. Nat. Acad. Sci. 71:1906, 1974.


6.   Jaffe, E.A. and Nachman, R.L. Subunit structure of factor VIII antigen synthesized by cultured human endothelial cells. J. Clin. Invest. 56:698-702, 1975.


7.   Nachman, R.L., Levine, R., and Jaffe, E.A. Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J. Clin. Invest. 60:914-921, 1977.


8.   Nachman, R.L., Jaffe, E.A., Miller, C., and Brown, W.T. Structural analysis of Factor VIII antigen in von Wille- brand's disease. Proc. Nat. Acad. Sci. U.S.A. 77:6832-6836, 1980.


9.   Leung, L., Kinoshita, T., and Nachman, R.L. Isolation, purification and partial characterization of platelet mem­brane glycoproteins IIb and IIIa. J. Biol. Chem. 256:1994-1997, 1981.


10.  Jaffe, E., Leung, L.L.K., Nachman, R.L., Levin, R., and Mosher, D.F. Thrombospondin is the endogenous lectin of human platelets. Nature 295:246-248, 1982.


11   Leung, L.L.K., and Nachman, R.L. Complex formation of platelet thrombospondin with fibrinogen. J. Clin. Invest. 70:542-549, 1982.


12.  Nachman, R.L., Leung, L.L.K., Kloczewiak, M., and Hawiger, J. Complex formation of platelet membrane glycoproteins IIb and IIIa with fibrinogen D domain. J. Biol. Chem.  259:8584-8588, 1984.


13.  Silverstein, R.L., Leung, L.L.K., Harpel, P.C., and Nachman, R.L. Complex formation of platelet thrombospondin with plasminogen: modulation of activation by tissue activator.  J. Clin. Invest. 74:1625-1633, 1984.


14.  Silverstein, R.L., Leung, L.L.K., Harpel, P.C. and Nachman, R.L. Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine rich glycoprotein.  J. Clin. Invest. 75:2065-2073, 1985.


15.  Nachman, R.L., Hajjar, K.A., Silverstein, R.L., and Dinarel­lo, C. Interleukin-1 induces endothelial cell synthesis of plasminogen activator inhibitor. J. Exp. Med. 163: 1595-1600, 1986.


16.  Silverstein, R.L. and Nachman, R.L. Thrombospondin binds to monocytes-macrophages and mediates platelet  monocyte adhesion. J. Clin.Invest. 79: 867-87, 1987.


17. Knudsen, B.S., Harpel, P.C., and Nachman, R.L. Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.  J. Clin. Invest. 80:1082-1089, 1987.


18.  Konkle, B.A., Shapiro, S.S., Asch, A.S., and Nachman, R.L. Cytokine enhanced expression of Glycoprotein 1ba in human endothelium. J.Biol.Chem. 265:19833-19838,1990.


19.  Etingin, O.R., Hajjar, D.P., Hajjar, K.A., Harpel, P.H., and Nachman, R.L.  Lipoprotein(a) regulates plasminogen activa­tor inhibitor-1 expression in endothelial cells: A potential mechanism in thrombogenesis.  J. Biol. Chem. 266:2459-2465, 1991.


20.  Asch, A.S., Tepler, J., Silbiger, S. and Nachman, R.L. Cellular attachment to TSP: Cooperative interactions between receptor systems. J. Biol. Chem. 266:1740-1745,1991.


21.  Nachman, R.L. Thrombosis and Atherogenesis: Molecular Connections. Blood 79:1897-1906, 1992.


22.  Nicholson, A., Nachman R.L., Altieri, D.C., Summers, B.D., Ruf, W., Edgington, T.S., and Hajjar., D. Effector cell protease receptor-1 is a vascular receptor for coagulation factors Xa.  J. Biol. Chem 271:28407-28413, 1996.


23.  Möhle, R., Green, D., Moore, M.A.S., Nachman, R.L., and Rafii, S. Constitutive Production and Thrombin-induced Release of Vascular Endothelial Growth Factor (VEGF) by Human Megakaryocytes and Platelets. Proc. Natl. Acad. Sci. (USA) 94:663-668, 1997


24.  Mohle, R., Moore, M.A.S., Nachman, R.L., Rafii, S.  Transendothelial migration of CD3 and nature hematopoietic cells: An in vitro study using human bone marrow endothelial cell.  Blood. 89: 72-80, 1997.


25.  Crombie, R., Silverstein, R.L., Maclow C, Pierce, S.F.A., Nachman, R.L., Laurence, J. Identification of a CD36-related Thrombospondin 1-binding Domain in HIV-1 Envelope Glycoprotein gp120:Relationship to HIV-1-specific Inhibitory Factors in Human Saliva.   J. Exp. Med.  187:25-36, 1998.


26.  Hamada, T., Mohle, R., Hesselgesser, J., Hoxie, J., Nachman, R.L., Moore, M.A.S., Rafii, S. Transendothial migration of megakaryocytes in response to stromal derived factor - 1 enhances platelet formation.  J. Exp. Med. 188:539-548, 1998.


27.  Simantov, R., Febbraio, M., Crombie, R., Asch, A., Nachman, R.L., Silverstein, R.  Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin -1. J. Clin. Invest.  107:45-52, 2001.


28.  Nachman, R.L.  Hypercoagulable States: Challenges and Opportunities. Trans. Am. Clin. Climatolog. Assoc.  112:161-179, 2001


29.  Nachman, R.L., and Jaffe, E.A.  Endothelial Cell Culture: Beginnings of Modern Vascular Biology. J. Clin. Invest.  114:1037-1040, 2004


30.  Nachman, R.L. Refractory Autoimmune Thrombocytopenia:  Response to Antiplatelet Therapy.  Lancet.  366:1410, 2005.  (Case Report)


31.  Nachman, R.L., Rafii, S.  Platelets, Petechiae, and Preservation of the Vascular Wall.  N. Eng.J. Med. 359:1261-1270, 2008. (Review Article)


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