Peter M. Okin, M.D.

Cardiovascular Disease

Publications

  • Okin PM, Kligfield P, Ameisen O, Goldberg H, Borer JS: Identification of anatomically extensive coronary artery disease by the exercise electrocardiographic ST segment/heart rate slope. Am Heart J 1988; 115:1002-1013.

  • Okin PM, Ameisen O, Kligfield P: Recovery phase patterns of ST segment depression in the heart rate domain: Identification of coronary artery disease by the rate recovery loop. Circulation 1989; 80:533-541.

  • Okin PM, Anderson KM, Levy D, Kligfield P: Heart rate adjustment of exercise-induced ST segment depression: Improved risk stratification in the Framingham Offspring Study. Circulation 1991; 83:866-874.

  • Okin PM, Bergman G, Kligfield P: Effect of ST segment measurement on performance of standard and heart rate adjusted ST segment criteria for the identification of coronary artery disease. Circulation 1991; 84:57-66.

  • Molloy TJ, Okin PM, Devereux RB, Kligfield P: Electrocardiographic detection of left ventricular hypertrophy by the simple QRS voltage-duration product. J Am Coll Cardiol 1992; 20:1180-1186.

  • Okin PM, Roman MJ, Devereux RB, Borer JS, Kligfield P: Electrocardiographic diagnosis of left ventricular hypertrophy by the time-voltage integral of the QRS. J Am Coll Cardiol 1994; 23:133-140.

  • Okin PM, Kligfield P: Solid angle theory and heart rate adjustment of ST segment depression for the identification and quantification of coronary artery disease. Am Heart J 1994; 127:658-667.

  • Okin PM, Roman MJ, Devereux RB, Kligfield P: Electrocardiographic identification of increased left ventricular mass by simple voltage duration products. J Am Coll Cardiol 1995; 25:417-423.

  • Okin PM, Roman MJ, Devereux RB, Kligfield P: Gender differences and the electrocardiogram in left ventricular hypertrophy. Hypertension 1995; 25:242-249.

  • Okin PM, Kligfield P: Heart rate adjustment of ST depression and performance of the exercise electrocardiogram: A critical evaluation. J Am Coll Cardiol 1995; 25:1726-1735.

  • Okin PM, Kligfield P: Gender-specific criteria and performance of the exercise electrocardiogram. Circulation 1995; 92:1209-1216.

  • Okin PM, Roman MJ, Devereux RB, Kligfield P: Electrocardiographic identification of left ventricular hypertrophy: test performance in relation to the definition of hypertrophy and the presence of obesity. J Am Coll Cardiol 1996; 27:124-131.

  • Okin PM, Roman MJ, Devereux RB, Kligfield P: Time-voltage area of the QRS for the identification of left ventricular hypertrophy. Hypertension 1996; 27:251-258.

  • Lauer MS, Okin PM, Larson MG, Evans JC, Anderson KM, Levy D: Impaired heart rate response to graded exercise: Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation 1996; 93:1520-1526.

  • Okin PM, Grandits G, Rautaharju PM, Prineas RJ, Cohen J, Crow R, Kligfield P: Prognostic value of heart rate adjustment of exercise ST segment depression in the Multiple Risk Factor Intervention Trial. J Am Coll Cardiol 1996; 27:1437-1443.

  • Okin PM, Roman MJ, Devereux RB, Kligfield P: The association of carotid atherosclerosis with electrocardiographic myocardial ischemia and left ventricular hypertrophy. Hypertension 1996; 28:3-7.

  • Okin PM, Lauer MS, Kligfield P: Chronotropic response to exercise: improved performance of ST segment depression criteria after adjustment for heart rate reserve. Circulation 1996; 94:3226-3231.

  • Lee KW, Okin PM, Kligfield P, Stein KM, Lerman BB: Precordial QT dispersion and inducible ventricular tachycardia. Am Heart J 1997; 134:1005-1013.

  • Okin PM, Prineas RJ, Grandits G, Rautaharju PM, Cohen JD, Crow RS, Kligfield P: Heart rate adjustment of exercise-induced ST segment depression identifies men who benefit from a risk factor reduction program. Circulation 1997; 96:2899-2904.

  • Okin PM, Roman MJ, Schwartz JE, Pickering TG, Devereux RB: The relation of exercise-induced electrocardiographic myocardial ischemia to cardiac and carotid structure and carotid atherosclerosis. Hypertension 1997; 30:1382-1388.

  • Okin PM, Roman MJ, Devereux RB, Pickering TG, Borer JS, Kligfield P: Time-voltage area of the QRS for the identification of left ventricular hypertrophy. Hypertension 1998; 31:937-942.

  • Lee KW, Kligfield P, Okin PM, Dower GE: Determinants of precordial QT dispersion in normal subjects. J Electrocardiol 1998; 31(Suppl):128-133..

  • Lauer MS, Mehta R, Pashkow FJ, Okin PM, Lee K, Marwick TH: Association of chronotropic incompetence with echocardiographic ischemia and prognosis. J Am Coll Cardiol 1998; 32:1280-1286.

  • Lauer MS, Francis GS, Okin PM, Pashkow FJ, Snader CE, Marwick TH: An impaired chronotropic response to exercise is a predictor of mortality, independent of ischemia and exercise capacity. JAMA 1999; 281:524-529.

  • Okin PM, Devereux RB, Howard BV, Fabsitz RR, Lee ET, Welty TK: Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians: The Strong Heart Study. Circulation; 2000; 101:61-66.

  • Liu JE, Hahn RT, Stein KM, Markowitz SM, Okin PM, Devereux RB, Lerman BB: Alterations in left ventricular geometry and function preceding neurally-mediated syncope. Circulation 2000; 101:777-783.

  • Okin PM, Jern S, Devereux RB, Kjeldsen SE, Dahlvf B: Effect of obesity on electrocardiographic left ventricular hypertrophy in hypertensive patients: The LIFE Study. Hypertension 2000;35 13?18.

  • Okin PM, Devereux RB, Jern S, Kjeldsen SE, Julius S, Dahlvf B: Baseline characteristics in relation to electrocardiographic left ventricular hypertrophy in hypertensive patients: the LIFE Study. Hypertension 2000; 36:766-773.

  • Lee KW, Kligfield P, Dower GE, Okin PM: QT dispersion, T wave projection, and heterogeneity of repolarization in patients with coronary artery disease. Am J Cardiol 2001; 87:148-151.

  • Vakili BA, Okin PM, Devereux RB: Prognostic implications of left ventricular hypertrophy. Am Heart J: 2001; 141:334?41.

  • Okin PM, Devereux RB, Nieminen MS, Jern S, Oikarinen L, Viitasalo M, Toivonen L, Kjeldsen SE, Julius S, Dahlvf B: Relationship of the electrocardiographic strain pattern to left ventricular structure and function in hypertensive patients: The LIFE Study. J Am Coll Cardiol 2001;38:514-520.

  • Okin PM, Devereux RB, Fabsitz RR, Lee ET, Galloway JM, Howard BV. Principal component analysis of the T-wave and prediction of cardiovascular mortality in American Indians: The Strong Heart Study. Circulation 2002; 105:714-719.

  • Okin PM, Wright JT, Nieminen MS, Jern S, Taylor AL, Phillips R, Papademetriou V, Clark LT, Ofili EO, Randall OS, Oikarinen L, Viitasalo M, Toivonen L, Julius S, Dahlvf B, Devereux RB: Racial differences in electrocardiographic criteria for left ventricular hypertrophy: The LIFE Study. Am J Hypertens 2002; 15:663-671

  • Okin PM, Devereux RB, Fabsitz RR, Lee ET, Galloway JM, Howard BV. Quantitative assessment of electrocardiographic strain predicts increased left ventricular mass: The Strong Heart Study. J Am Coll Cardiol 2002;40:1395-1400.

  • Oikarinen L, Nieminen MS, Toivonen L, Viitasalo M, Wachtell K, Papademetriou V, Jern S, Dahlvf B, Devereux RB, Okin PM, For the LIFE Study Investigators: Relation of QT interval and QT dispersion to regression of echocardiographic and electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan Intervention for Endpoint Reduction (LIFE) Study. Am Heart J 2003;5:919-925.

  • Palmieri V, Okin PM, Bella JN, Gerdts E, Wachtell K, Gardin J, Papademetriou V, Nieminen MS, Dahlvf B, Devereux RB: Echocardiographic wall motion abnormalities in hypertensive patients with ECG left ventricular hypertrophy: The LIFE Study. Hypertension 2003;41:75-82..

  • Okin PM, Devereux RB, Jern S, Kjeldsen SE, Julius S, Nieminen MS, Snapinn S, Harris KE, Aurup P, Edelman JM, Dahlvf B: Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The LIFE Study. Circulation 2003;108:684-690.

  • Wachtell K, Ibsen H, Olsen MH, Borch-Johnsen K, Lindholm LH, Mogensen CE, Dahlvf B, Devereux RB, Beevers G, de Faire U, Fyhrquist F, Julius S, Kjeldsen SE, Kristianson K, Lederballe-Pedersen O, Nieminen MS, Okin PM, Omvik P, Oparil S, Wedel H, Snapinn SM, Aurup P. Albuminuria and Cardiovascular Risk in Hypertensive Patients with Left Ventricular HypertrophyThe LIFE Study Ann Internal Med 2003;139:901-906.

  • Okin PM, Devereux RB, Lee ET, Galloway JM, Howard BV. Ventricular repolarization complexity and abnormality predict all-cause and cardiovascular mortality in diabetes: The Strong Heart Study Diabetes 2004;53:434-440.

  • Okin PM, Roman MJ, Lee ET, Galloway JM, Howard BV, Devereux RB. Combined echocardiographic left ventricular hypertrophy and electrocardiographic ST depression improve prediction of mortality in American Indians: The Strong Heart Study. Hypertension 2004;43:769-774.

  • Okin PM, Devereux RB, Nieminen MS, Jern S, Oikarinen L, Viitasalo M, Toivonen L, Kjeldsen SE, Julius S, Snapinn S, Dahlöf B: Electrocardiographic strain pattern and prediction of cardiovascular morbidity and mortality in hypertensive patients. Hypertension 2004;44:48-54.

  • Okin PM, Devereux RB, Jern S, Kjeldsen SE, Julius S, Nieminen MS, Snapinn S, Harris KE, Aurup P, Edelman JM, Wedel H, Lindholm LH, Dahlöf B: Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and prediction of major cardiovascular events: The LIFE Study. JAMA 2004;292:2343-2349.

  • Okin PM, Roman MJ, Best LG, Lee ET, Galloway JM, Howard BV, Devereux RB. C-reactive protein and electrocardiographic ST segment depression additively predict mortality: The Strong Heart Study. J Am Coll Cardiol 2005;45:1787-1793.

  • Okin PM, Marek M, Hnatkova K, Lee ET, Galloway JM, Best LG, Howard BV, Devereux RB: Repolarization abnormality for prediction of all-cause and cardiovascular mortality in American Indians: The Strong Heart Study. J Cardiovasc Electrophys 2005;16:945-951.

  • Okin PM, Devereux, RB, Nieminen, MS, Jern S, Oikarinen L, Viitasalo M, Toivonen L, Kjeldsen SE, Dahlöf B: Electrocardiographic strain pattern and prediction of new-onset congestive heart failure in hypertensive patients: The LIFE Study. Circulation 2006;113:67-73.

  • Okin PM. Electrocardiographic in women: taking the initiative. Circulation 2006;113:464-466.

  • Okin PM, Devereux RB, Gerdts E, Snapinn S, Harris KE, Jern S, Kjeldsen SE, Julius S, Edelman JM, Lindholm LH, Dahlöf B: The impact of diabetes on regression of electrocardiographic left ventricular hypertrophy and the prediction of outcomes during antihypertensive therapy: the LIFE Study. Circulation 2006; 113:1588-1596.

  • Olsen MH, Wachtell K, Ibsen H, Lindholm LH, Dahlöf B, Devereux RB, Julius S, Kjeldsen SE, Oikarinen L, Okin PM. Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE Study. J Hypertens 2006; 24:775-781.

  • Kjeldsen SE, Strand A, Julius S, Okin PM. Mechanism of angiotensin II type 1 receptor blocker action on the improvement of left ventricular hypertrophy. J Clin Hypertens 2006;8:487-492.

  • Palmieri V, Okin PM, Bella JN, Wachtell K, Oikarinen L, Gerdts E, Boman K, Nieminen MS, Dahlöf B, Devereux RB. Electrocardiographic strain pattern and left ventricular diastolic function in hypertensive patients with left ventricular hypertrophy: the LIFE Study. J Hypertension 2006;24:2079-2084.

  • Okin PM, Wachtell K, Devereux RB, Harris KE, Jern S, Kjeldsen SE, Julius S, Lindholm L, Nieminen MS, Edelman JM, Dahlöf B. Regression of electrocardiographic left ventricular hypertrophy and decreased incidence of new-onset atrial fibrillation: the LIFE Study. JAMA 2006;296:1242-1248.

  • Kligfield P, Okin PM. Prevalence and clinical implications of improper filter settings in routine electrocardiography. Am J Cardiol 2007;99:711-713.

  • Palmieri V, Okin PM, de Simone G, Bella JN, Wachtell K, Gerdts E, Boman K, Nieminen MS, Dahlöf B, Devereux RB. Electrocardiographic characteristics and metabolic risk factors associated with inappropriately high left ventricular mass in patients with electrocardiographic left ventricular hypertrophy: the LIFE Study. J Hypertens 2007;25:1079-1085.

  • Cicala S, Devereux RB, de Simone G, Wachtell K, Gerdts E, Boman K, Nieminen M, Papademetriou V, Dahlöf B, Okin PM. Electrocardiographic or echocardiographic detection of myocardial infarction in patients with left ventricular hypertrophy: The LIFE Study. Am J Hypertension 2007;20:771-776.

  • Wachtell, Okin PM, Olsen MH, Dahlöf B, Devereux RB, Ibsen H, Kjeldsen SE, Lindholm LH, Nieminen MS, Thygesen K. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapy and reduction in sudden cardiac death: the LIFE Study. Circulation 2007;116:700-705.

  • Okin PM, Devereux RB, Harris KE, Jern S, Kjeldsen SE, Julius S, Edelman JM, Dahlöf B, for the LIFE Study Investigators. Reduction of electrocardiographic left ventricular hypertrophy is associated with decreased heart failure hospitalization in hypertensive patients. Ann Intern Med 2007;147:311-319.

  • Okin PM, Roman MJ, Lee ET, Galloway JM, Best LG, Howard BV, Devereux RB. Usefulness of quantitative assessment of electrocardiographic ST depression for predicting new-onset heart failure in American Indians (from the Strong Heart Study). Am J Cardiol 2007;100:94-98.

  • Min JK, Shaw LJ, Devereux RB, Okin PM, Weinsaft JW, Russo DJ, Lippolis NJ, Callister TQ. Prognostic value of multidetector coronary CT angiography for prediction of all-cause mortality. J Am Coll Cardiol 2007;50:1161-1170.

  • Weinsaft JW, Gade CL, Wong FJ, Kim HW, Min JK, Manoushagian SJ, Okin PM, Szulc M. Diagnostic impact of SPECT image display on assessment of obstructive coronary artery disease. J Nucl Cardiol 2007;14:659-668.

  • Okin PM, Devereux RB, Harris KE, Jern S, Kjeldsen SE, Lindholm LH, Dahlöf B, for the LIFE Study Investigators. In-treatment resolution or absence of electrocardiographic left ventricular hypertrophy is associated with decreased incidence of new-onset diabetes mellitus in hypertensive patients: the LIFE Study. Hypertension 2007;50:984-990.

  • Lin F, Shaw LJ, Berman DS, Callister TQ, Weinsaft JW, Wong FJ, Szulc M, Tandon V, Okin PM, Devereux RB, Min JK. Multidector computed tomography by coronary artery plaque predictors of stress-induced myocardial ischemia by SPECT. Atherosclerosis 2008:197:700-709.

  • Okin PM, Wachtel K, Devereux RB, Nieminen MS, Oikarinen L, Viitasalo M, Toivonen L, Ibsen H, Olsen MH, Borch-Johnsen K, Lindholm LH, Kjeldsen SE, Julius S, Dahlöf B, For the LIFE Study Investigators. Combination of the electrocardiographic strain pattern and albuminuria for the prediction of new-onset heart failure in hypertensive patients: the LIFE Study. Am J Hypertension 2008;21:273-279.

  • Gerdts E, Okin PM, de Simone G, Cramariuc D, Wachtell K, Boman K, Devereux RB. Gender differences in left ventricular structure and function during antihypertensive treatment; The Losartan Intervention For Endpoint Reduction in Hypertension Study. Hypertension 2008;51:1109-1114.

  • Os I, Franco V, Kjeldsen SE, Manhem K, Devereux RB, Gerdts E, Hille DA, Lyle PA, Okin PM, Dahlöf B, Oparil S. Effects of losartan in women with hypertension and left ventricular hypertrophy. Results from the Losartan Intervention For Endpoint Reduction in Hypertension Study. Hypertension 2008;51:1103-1108.

  • Li Z, Dahlöf B, Okin PM, Kjeldsen SE, Wachtell K, Ibesn H, Nieminen MS, Jern S, Devereux RB. Left bundle branch block and cardiovascular morbidity and mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension study. J Hypertens 2008;26:1244-1249.

  • Okin PM, Gerdts E, Kjeldsen SE, Julius S, Edelman JM, Dahlöf B, Devereux RB. Gender differences in regression of electrocardiographic left ventricular hypertrophy in response to antihypertensive therapy: the LIFE Study. Hypertension 2008;52:100-106.

  • Back to topBack To Top