Mark I. Rosenblatt, M.D., Ph.D.

Ophthalmology

Publications

Original Research and Theoretical Treatises

1. Rosenblatt MI, Dickerson IM. (1997). “Endoproteolysis at tetrabasic amino acid sites in procalcitonin gene-related peptide by pituitary cell lines.” Peptides; 18(4):567-76.

2. Naghashpour M, Rosenblatt MI, Dickerson IM, Dahl GP. (1997). “Inhibitory effect of calcitonin gene-related peptide on myometrial contractility is diminished at parturition.” Endocrinology ;138(10):4207-14.

3. Rosenblatt MI, Dahl GP, Dickerson IM. (2000). “Characterization and localization of the rabbit ocular calcitonin gene-related peptide (CGRP)-receptor component protein (RCP).” Invest Ophthalmol Vis Sci.;41(5):1159-67.

4. Evans BN, Rosenblatt MI, Mnayer LO, Oliver KR, Dickerson IM. (2000). “CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.” J Biol Chem.;275(40):31438-43.

5. Solomon A, Rosenblatt M, Li DQ, Liu Z, Monroy D, Ji Z, Lokeshwar BL, Pflugfelder SC. (2000). “Doxycycline inhibition of interleukin-1 in the corneal epithelium.” Invest Ophthalmol Vis Sci.;41(9):2544-57.

6. Solomon A, Rosenblatt M, Monroy D, Ji Z, Pflugfelder SC, Tseng SC. (2001). “Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix.” Br J Ophthalmol;85(4):444-9.

7. Yu CQ, Rosenblatt MI. (2007). “Transgenic corneal neurofluorescence in mice: a new model for in vivo investigations of nerve structure and regeneration.” Invest Ophthalmol Vis Sci. 48(4):1535-42. (Including cover illustration).

8. Ghoghawala SY, Mannis MJ, Murphy CJ, Rosenblatt MI, Isseroff RR. (2007) “Economical LED based, real-time, imaging of in vivo murine wound healing.” Exp Eye Res. 84(6):1031-8.

9. Ghoghawala SY, Mannis MJ, Rosenblatt MI, Isseroff RR. (2008) “The ß2-Adrenergic Receptor Mediates Corneal Epithelial Wound Repair.” Invest Ophthalmol Vis Sci. In press.

Dissertations

1. “Calcitonin Gene-Related Peptide: Biosynthesis and Receptor Activation.” Doctoral dissertation completed for Doctor of Philosophy degree issued by the University of Miami School of Medicine in May 1999.

Reviews

1. Chang JH, Rosenblatt MI. (2002) “Corneal neovascularization:imbalance between angiogenic and antiangiogenic factors.” Middle East Journal of Ophthalmology;10(2):89-96.

2. Rosenblatt MI, Azar DT. (2004). “Gene therapy of the corneal epithelium.” International Ophthalmology Clinics. 44(3):81-90.

3. Rosenblatt MI, Azar DT. (2006) “Anti-angiogenic therapy: prospects for the treatment of ocular tumors.” Seminars in Ophthalmology. 21(3):151-60.

4. Sakimoto T, Rosenblatt MI, Azar DT. (2006). “Laser eye surgery for refractive errors.” The Lancet. 367: 1432-1447.

Abstracts

1. Rosenblatt MI, Dahl GP, Dickerson IM. (1995). “Neuropeptide effects on ciliary body/iris cAMP levels as measured by a sensitive oocyte-based assay.” Invest Ophthalmol Vis Sci. Abstr;36, S593.

2. Rosenblatt MI, Dickerson IM. (1996). “Endoproreolysis of procalcitonin gene-related peptide mutated at the tetrabasic amino acid site.” Eastern Student Research Forum, 2/22/96-2/24/96, Miami, FL.

3. Rosenblatt MI, Paul L, Dahl GP, Dickerson IM. (1996). “Cloning of a molecule from the ciliary body which confers responsiveness to calcitonin gene-related peptide.” Invest Ophthalmol Vis Sci Abstr;37, S583.

4. Rosenblatt MI, Dickerson IM. (1997). “Endoproteolysis at tetrabasic amino acid sites: Analysis of procalcitonin gene-related peptide (proCGRP) mutants.” Tenth Intenational Congress of Endocrinology, 6/12/96-6/15/98, San Francisco, CA.

5. Rosenblatt MI, Dahl GP, Dickerson IM. (1997). “The ciliary body/iris and non-pigmented epithelium cell lines express calcitonin gene-related peptide and calcitonin receptors.” Invest Ophthalmol Vis Sci Abstr;38, S820.

6. Rosenblatt MI, Serralta V, Luebke AE, Dahl GP, Dickerson IM. (1997). “Characterization of a novel low molecular weight protein required for signal transduction at the CGRP receptor.” Gordon Conference on Second Messengers and Protein Phosphorylation, 6/8/97-6/13/97, Meriden, NH.

7. Rosenblatt MI, Evans BN, Naghashpour M, Mnayer L, Luebke AE, Dahl GP, Dickerson IM. (1998). “The CGRP-receptor component protein: a novel signal transduction protein.” Third International Meeting on Calcitonin Gene-Related Peptide, 5/11/98-5/12/98, Shaftsbury, UK.

8. Dickerson IM, Rosenblatt MI, Evans BN, Dahl GP. (1998). “Calcitonin Gene-Related Peptide receptors in ocular tissues.” Thirteenth International Congress of Eye Research, 7/26/98-7/31/98, Paris, France.

9. Rosenblatt MI, Thompson H, Ray SK. (2001). “Post-operative target refraction following intraocular lens implantation.” Invest Ophthalmol Vis Sci Abstr, 4/29/01-5/4/01, Ft. Lauderdale, FL.

10.Rosenblatt MI, Chang JH, Chen CC, Azar DT. (2002). “Gene Transfer into Mouse Corneal Epithelial Cell Lines Using an Ecdysone Regulated Ecotropic Retroviral Vector System.” Invest Ophthalmol Vis Sci Abstr, 5/5/02-5/10/02, Ft. Lauderdale, FL.

11. Rosenblatt MI, Ye SI,.Chan JH, Azar DT. (2004) “Gene Transfer of Matrix Melloproteinase-7 (MMP-7) to Corneal Cell Lines.” Invest Ophthalmol Vis Sci Abstr, 4/25/04-4/29/04, Ft. Lauderdale, FL.

12. Casanova FH, Yu A, Varintorn C,.Yeh SI ,.Escalona E ,.Chung TY,.Javier J, Rosenblatt MI, Chang JH, Azar DT. (2005) “Effect of MT1-MMP Knockout and Knock-In Corneal Epithelial Cells and Keratocytes on Vascular Endothelial Cell Migration and Proliferation.” Invest Ophthalmol Vis Sci Abstr, 5/1/05-5/5/05, Ft. Lauderdale, FL.

13. Casanova FH, Yu A, Varintorn C,.Yeh SI ,.Escalona E ,.Chung TY,.Javier J, Rosenblatt MI, Chang JH, Azar DT. (2005) “Effect of MT1-MMP Knockout and Knock-In Corneal Epithelial Cells and Keratocytes on Vascular Endothelial Cell Migration and Proliferation.” Invest Ophthalmol Vis Sci Abstr, 5/1/05-5/5/05, Ft. Lauderdale, FL.

14. Rosenblatt MI, Nimigean CM, Azar DT. (2005) “Modeling Corneal Cell Kinetics: Implications for Gene Transfer.” Invest Ophthalmol Vis Sci Abstr, 5/1/05-5/5/05, Ft. Lauderdale, FL.

15. Kim C, Oliveira LA, Chirila TV, Zainuddin, Schwab IR, Rosenblatt MI. “Bombyx mori Silk Fibroin as a Biomatrix Substrate for ex vivo Expansion of Human and Rabbit Corneal Epithelial Cells.” Invest Ophthalmol Vis Sci Abstr, 5/5/07-5/10/07, Ft. Lauderdale, FL.

16. Zhang M, Rosenblatt MI. “Expression of Semaphorin and VEGF Ligands and Receptors Following Superficial Corneal Injury.” Invest Ophthalmol Vis Sci Abstr, 5/5/07-5/10/07, Ft. Lauderdale, FL.

17. Matis K, Rosenblatt MI. “Corneal Innervation During Mouse Embryonic Development.” Invest Ophthalmol Vis Sci Abstr, 5/5/07-5/10/07, Ft. Lauderdale, FL.

18. Yu CQ, Rosenblatt MI. “Transgenic Corneal Neurofluorescence in Mice: A New Model for in vivo Investigations of Nerve Structure and Regeneration.” Invest Ophthalmol Vis Sci Abstr, 5/5/07-5/10/07, Ft. Lauderdale, FL.

19. Rosenblatt MI, Oliveira LA, Schwab IR, Kashiwabushi RT, Yu MCZ, Sampath R, Blyn LB, deSousa, LB, Ecker DJ. “High-Throughput Molecular Diagnostics for the Rapid Detection of Pathogens in Corneal Ulcers.” Invest Ophthalmol Vis Sci Abstr, 5/5/07-5/10/07, Ft. Lauderdale, FL.

20. Oliveira LA, Kim C, Schwab IR, Rosenblatt MI. “Gene Transfer to Primary Corneal Epithelial Cells Ex Vivo.” Invest Ophthalmol Vis Sci Abstr, 5/5/07-5/10/07, Ft. Lauderdale, FL.

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