Costantino Iadecola, M.D.

Neurology

Publications

Iadecola C, Zhang F, Niwa K, Eckman C, Younkin S, Turner SK, Fischer E, Borchell D, Hsiao KK and Carlson GA: SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci. 2: 157-161, 1999.

Niwa K, Araki E, Morham S, Ross ME and Iadecola C: Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci. 20: 763-770, 2000.

Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, Hsiao Ashe K, Carlson GA and Iadecola C: Aß1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci (USA), 97: 9735-9740, 2000.

Yang G, Huard J, Beitz AJ, Ross ME and Iadecola C: Stellate neurons mediate functional hyperemia in cerebellar molecular layer. J Neurosci. 20: 6968-6973, 2000.

Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S and Ross ME: Reduced susceptibility to ischemic brain injury and NMDA-mediated neurotoxicity in cyclooxygenase-2 deficient mice. Proc Natl Acad Sci (USA), 98: 1294-1299, 2001.

Iadecola C: Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci. 5: 347-360, 2004.

Wang G, Anrather J, Huang J, Speth RB, Pickel VM and Iadecola C: NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J Neurosci. 24: 5516-5524, 2004.

Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner TA and Iadecola C: Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res. 95: 1019-1026, 2004.

Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA and Iadecola C: NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 25: 1769-1777, 2005.

Cho S, Park EM, Febbraio M, Anrather J, Park L, Racchumi G, Silverstein RL and Iadecola C: The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J Neurosci. 25: 2504-2512, 2005.

Kawano T, Anrather J, Zhou P, Park L, Wang G, Frys KA, Kunz A, Cho S, Orio M and Iadecola C: Prostaglandin E2 EP1 receptors: Downstream effectors of COX-2 neurotoxicity. Nat Med. 12: 225-229, 2006.

Girouard H, Park L, Anrather J, Zhou P and Iadecola C: Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. Arterioscler Thromb Vasc Biol. 27: 303-309, 2007.

Iadecola C: Astrocytes take center stage in salt sensing. Neuron, 54: 3-5, 2007.

Kunz A, Park L, Abe T, Gallo EF, Anrather J, Zhou P and Iadecola C: Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J Neurosci. 27: 7083-7093, 2007.

Iadecola C and Nedergaard M: Glial regulation of the cerebral microvasculature. Nat Neurosci. 10: 1369-1376, 2007.

Kunz A, Abe T, Hochrainer K, Shimamura M, Anrather J, Racchumi G, Zhou P and Iadecola C: Nuclear factor-kb activation and post-ischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion. J Neurosci. 28: 1649-1658, 2008.

Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS and Iadecola C: Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci (USA), 105: 1347-1352, 2008.

Park L, Gallo EF, Anrather J, Wang G, Norris EH, Paul J, Strickland S and Iadecola C: Key role of tissue plasminogen activator in neurovascular coupling. Proc Natl Acad Sci (USA), 105: 1073-1078, 2008.

Girouard H, Wang G, Gallo EF, Anrather J, Zhou P, Pickel VM and Iadecola C: NMDA receptor activation increases free radical production through nitric oxide and NOX2. J Neurosci. 29: 2545-2552, 2009.

Capone C, Anrather J, Milner TA and Iadecola C: Estrous cycle dependent neurovascular dysfunction induced by angiotensin II in the mouse neocortex. Hypertension, 54: 302-307, 2009.

Iadecola C: Bleeding in the brain: Killer waves of depolarization in subarachnoid bleed. Nat Med. 15: 1131-1132, 2009.

Yin F Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, Beal MF, Nathan C and Ding A: Exaggerated Inflammation and Brain Dysfunction in Progranulin- Deficient Mice. J Exp Med. 207: 117-128, 2010.

Capone C, Faraco, G, Anrather J, Zhou P and Iadecola C: COX-1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension, 55 :911-917, 2010.

Abe T, Shimamura M, Jackman K, Kurinami H, Anrather J, Zhou P and Iadecola C: Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia. Stroke, 41:898-904, 2010.

Iadecola C: The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropath, 120: 287-296, 2010.

Moskowitz MA, Lo E and Iadecola C: The Science of Stroke: Mechanisms in Search of Treatments. Neuron, 67: 181-198, 2010.

Coleman C, Wang G, Park L, Anrather J, Delagrammatikas G, Chan J, Zhou J, Iadecola C and Pickel VM: Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. J Neurosci. 30: 12103-12112, 2010.

Gallo EF, Iadecola C: Balancing life and death in the ischemic brain: SIK and TORK weigh in. Neuron, 69: 3-6, 2011.

Newelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnar Z, O'Donnell M, Povlishock J, Saunders N, Sharp F, Stanimirovic D, Watts R and Drewes L: Engaging Neuroscience to Advance Translational Research in Brain Barrier Biology. Nat Rev Neurosci. 12: 169-182, 2011.

Park L, Wang G, Zhou P, Zhou J, Pistick R, Previti ML, Younkin L, Younkin S, Van Nostrand WE, Cho S-G, Anrather J, Carlson G and Iadecola C: The scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-b. Proc Natl Acad Sci (USA), 108: 5063-5068, 2011.

Iadecola C and Anrather J: The immunology of stroke: from mechanisms to translation. Nat Med. 17: 796-808, 2011.

Gallo EF and Iadecola C: Neuronal Nitric Oxide Contributes to Neuroplasticity-Associated Protein Expression through cGMP, Protein Kinase G, and Extracellular Signal-Regulated Kinase. J Neurosi. 31: 6947-6955, 2011.

Gorelick PB, Scuteri A, Black SE, DeCarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW and Seshadri S: Vascular Contributions to Cognitive Impairment and Dementia. Stroke, 42: 2672-2713, 2011.

Iadecola C and Anrather J: Stroke research at a crossroad: asking the brain for directions. Nat Neurosci. 14: 1363-1368, 2011.

Zhou P Qian L, D'Aurelio M, Cho S, Wang G, Manfredi G, Pickel VM and Iadecola C: Prohibitin Reduces Mitochondrial Free Radical Production and Protects Brain Cells from Different Injury Modalities. J Neurosci. 32: 583-592, 2012.

Capone C, Faraco G, Peterson J, Coleman C, Anrather J, Milner TA, Pickel VM, Davisson RL and Iadecola C: Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin-II hypertension. J Neurosci. 32:4878-4886, 2012.

Kamel, H., Johnston, S.C., Kirkham, J. C., Turner, C. G., Kizer, J. R., Devereux, R.B., and Iadecola, C.: Association Between Major Perioperative Hemorrhage and Stroke or Q-Wave Myocardial Infarction. Circulation, 126:207-212, 2012

Garcia-Bonilla, L., and Iadecola: Peroxiredoxin sets the brain on fire after stroke. Nature Medicine, 18:858-859, 2012

Young, C., Cao X., Guruju, M., Pierce, J., Morgan, D., Wang, G., Iadecola, C., Mark, A.L., Davisson R.L.: Endoplasmic Reticulum Stress in the Brain Subfornical Organ Mediates Angiotensin-Dependent Hypertension. J. Clin Invest., 122: 3960-4, 2012

Woo, M-S, Wang, X., Faustino, J.V., Derugin, N., Wendland, M.F., Zhou, P., Iadecola, C., Vexler, Z.S.: Genetic deletion of CD36 enhances injury after acute neonatal stroke. Ann Neurol, 72:961-970, 2012

Park L., Zhou, J., Zhou, P., Pistick, R., El Jamal, S., Younkin, L., Pierce, J., Arreguin, A., Anrather, J., Younkin, S.G., Carlson, G.C., McEwen, B., and Iadecola, C.: Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc. Natl. Acad. Sci. USA, 2013

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