Hugh C. Hemmings Jr., M.D., Ph.D.



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Herold, KF, Hemmings HCJr. Sodium channels as targets for volatile anesthetics. Front Pharmacol 2012; 3:50 (PMID: 22479247)

Westphalen RI, Kwak NB, Daniels K, Hemmings HC Jr. Regional differences in the effects of isoflurane on neurotransmitter release. Neuropharmacology. 2011 Sep;61(4):699-706.

Mantz J, Hemmings HC Jr. Sleep and anesthesia: the histamine connection.
Anesthesiology. 2011 Jul;115(1):8-9.

Hudson AE, Hemmings HC Jr. Are anaesthetics toxic to the brain? Br J Anaesth.
2011 Jul;107(1):30-7.

Hemmings HC Jr, Mackie K. The rivers of lethe and mnemosyne converge: propofol and memory consolidation. Anesthesiology. 2011 Jun;114(6):1277-9.

Hemmings HC Jr, Rosenberg AD, Reilly CS, Hunter JM. The 2010 BJA/PGA
supplement: a selection of 10 educational reviews. Br J Anaesth. 2010 Dec;105
Suppl 1:i1-2.

Bendor J, Lizardi-Ortiz JE, Westphalen RI, Brandstetter M, Hemmings HC Jr,
Sulzer D, Flajolet M, Greengard P. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. EMBO J. 2010 Aug

Hemmings HC Jr, Greengard P. Positively active: how local anesthetics work. Anesthesiology. 2010 Jul;113(1):250-2.

Westphalen RI, Yu J, Krivitski M, Jih TY, Hemmings HC Jr. Regional differences in nerve terminal Na channel subtype expression and Na channel-dependent glutamate and GABA release in rat CNS. J Neurochem. 2010 Jun;113(6):1611-20.

Glausier JR, Maddox M, Hemmings HC Jr, Nairn AC, Greengard P, Muly EC.
Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex. Neuroscience. 2010 May 5;167(2):428-38.

Zhang Y, Guzinski M, Eger EI 2nd, Laster MJ, Sharma M, Harris RA, Hemmings HC Jr. Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats. Br J Pharmacol. 2010 Feb;159(4):872-8.

Mantz J, Hemmings HC Jr, Boddaert J. Case scenario: postoperative delirium in
elderly surgical patients. Anesthesiology. 2010 Jan;112(1):189-95.

Perouansky M, Hemmings HC Jr. Neurotoxicity of general anesthetics: cause for
concern? Anesthesiology. 2009 Dec;111(6):1365-71.

Twersky RS, Hemmings HC Jr. Introduction: 2009 BJA/PGA Supplement: a
selection of eight reviews. Br J Anaesth. 2009 Dec;103 Suppl 1:i1-2.

Herold KF, Nau C, Ouyang W, Hemmings HC Jr. Isoflurane inhibits the
tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology. 2009 Sep;111(3):591-9

Hemmings HC Jr. Sodium channels and the synaptic mechanisms of inhaled anaesthetics. Br J Anaesth. 2009 Jul;103(1):61-9. Review. PMID: 19508978

Perouansky M, Hemmings HC Jr. Between Clotho and Lachesis: how isoflurane seals neuronal fate. Anesthesiology. 2009 Apr;110(4):709-11. PMID: 19276964

Ouyang W, Herold KF, Hemmings HC Jr. Comparative effects of halogenated inhaled anesthetics on voltage-gated Na channel function. Anesthesiology. 2009 Mar;110(3):582-90. PMID: 19225394

Westphalen RI, Gomez RS, Hemmings HC Jr. Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane. Br J Anaesth. 2009 Mar;102(3):355-60. PMID: 19189985

Hemmings HC Jr, Mantz J. Xenon and the pharmacology of fear. Anesthesiology. 2008 Dec;109(6):954-5. PMID: 19034089

Zhang Y, Sharma M, Eger EI 2nd, Laster MJ, Hemmings HC Jr, Harris RA. Intrathecal veratridine administration increases minimum alveolar concentration in rats. Anesth Analg. 2008 Sep;107(3):875-8. PMID: 18713899

Eger EI 2nd, Raines DE, Shafer SL, Hemmings HC Jr, Sonner JM. Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008 Sep;107(3):832-48. Review. PMID: 18713892

Hemmings HC Jr, Flood P. Galloping in full pursuit of the mechanism of anesthetic immobility. Anesthesiology. 2008 Jun;108(6):975-6. PMID: 18497595

Platholi J, Heerdt PM, Lim Tung HY, Hemmings HC Jr. Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma. J Neurochem. 2008 Jun;105(5):2029-38. Epub 2008 Feb 14. PMID: 18284617

Zhang TT, Platholi J, Heerdt PM, Hemmings HC Jr, Tung HY. Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation. Metab Brain Dis. 2008 Mar;23(1):95-104. Epub 2008 Jan 16. PMID: 18197471

Hemmings HC Jr. Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor. Anesthesiology. 2007 Nov;107(5):694-6. PMID: 18073542

Westphalen RI, Krivitski M, Amarosa A, Guy N, Hemmings HC Jr. Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45. Epub 2007 Sep 10. PMID: 17828284

Snyder GL, Galdi S, Hendrick JP, Hemmings HC Jr. General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology. 2007 Oct;53(5):619-30. Epub 2007 Jul 24. PMID: 17826804

OuYang W, Hemmings HC Jr. Isoform-selective effects of isoflurane on voltage-gated Na channels. Anesthesiology. 2007 Jul;107(1):91-8. PMID: 17585220

Ouyang W, Jih TY, Zhang TT, Correa AM, Hemmings HC Jr. Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel. J Pharmacol Exp Ther. 2007 Sep;322(3):1076-83. Epub 2007 Jun 14. PMID: 17569823

Bullock SA, Platholi J, Gjyrezi A, Heerdt PM, Tung HY, Hemmings HC Jr. Differential regulation of protein phosphatase-1(I) by neurabin. Biochem Biophys Res Commun. 2007 Jun 22;358(1):140-4. Epub 2007 Apr 19. PMID: 17467665

Nguyen C, Nishi A, Kansy JW, Fernandez J, Hayashi K, Gillardon F, Hemmings HC Jr, Nairn AC, Bibb JA. Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. J Biol Chem. 2007 Jun 1;282(22):16511-20. Epub 2007 Mar 30. PMID: 17400554

Hotte M, Thuault S, Dineley KT, Hemmings HC Jr, Nairn AC, Jay TM. Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo. Synapse. 2007 Jan;61(1):24-8. PMID: 17068779

Bruening S, Oh E, Hetzenauer A, Escobar-Alvarez S, Westphalen RI, Hemmings HC Jr, Singewald N, Shippenberg T, Toth M. The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system. J Neurochem. 2006 Nov;99(3):892-9. Epub 2006 Aug 21. PMID: 16925594

Hemmings HC Jr, Antognini JF. Do general anesthetics add up? Anesthesiology. 2006 Jun;104(6):1120-2. PMID: 16732079

Hotte M, Thuault S, Lachaise F, Dineley KT, Hemmings HC, Nairn AC, Jay TM. D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. Behav Brain Res. 2006 Jul 15;171(1):127-33. Epub 2006 May 9. PMID: 16687181

Westphalen RI, Hemmings HC Jr. Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: Basal Release. J Pharmacol Exp Ther. 2006 Jan;316(1):208-15.

Westphalen RI, Hemmings HC Jr. Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: 4-Aminopyridine-Evoked Release. J Pharmacol Exp Ther. 2006 Jan;316(1):216-23.

Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci. 2005 Oct;26(10):503-10. Review. Foundations of Anesthesia: Basic Sciences for Clinical Practice 2e, HC Hemmings Jr, PM Hopkins, eds (2006; Mosby Elsevier, London).

Hemmings HCJr, Yan W, Westphalen RI, Ryan TA (2005) The general anesthetic isoflurane depresses synaptic vesicle exocytosis. Mol Pharmacol 67:1591-9.

Fu D, Vissavajjhala P, Hemmings HC Jr. (2005) Volatile anaesthetic effects on phospholipid binding to synaptotagmin 1, a presynaptic Ca2 sensor. Br J Anaesth. 95:216-21.

Futter M, Uematsu K, Bullock SA, Kim Y, Hemmings HC Jr, Nishi A, Greengard P, Nairn AC. (2005) Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). Proc Natl Acad Sci USA 102:3489-94.

OuYang W, Wang G, Hemmings HC Jr. (2004) Distinct rat neurohypophysial nerve terminal populations identified by size, electrophysiological properties and neuropeptide content. Brain Res. 1024:203-11.

Ouyang W, Hemmings HC Jr. (2004) Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals. J Pharmacol Exp Ther. 312:801-8.

Morrow PW, Tung HY, Hemmings HC Jr. (2004) Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4 T cells. Biochem Biophys Res Commun. 323:645-51.

Balint E, Kitka T, Zachar G, Adam A, Hemmings HC Jr, Csillag A. (2004)Abundance and location of DARPP-32 in striato-tegmental circuits of domestic chicks. J Chem Neuroanat. 28:27-36.

Hemmings HC Jr. (2004) Neuroprotection by Na channel blockade. J Neurosurg anesthesiol. 16:100-1. Review.

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