Ethel Cesarman, M.D., Ph.D.

Anatomic Pathology and Clinical Pathology


Representative of >140 publications:

  • Chang Y, Cesarman E, Pessin M, Lee F, Culpepper J, Knowles DM, Moore PS: Identification of new human herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science, 266:1865-1869, 1994.
  • Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM: Kaposi's sarcoma-associated herpesvirus-like DNA sequences are present in AIDS-related body cavity based lymphomas. New Engl J Med, 332:1186-1191, 1995.
  • Arvanitakis L, Geras-Raaka E, Gershengorn MC, Cesarman E. KS herpesvirus encodes a constitutively active G protein-coupled receptor linked to cell proliferation. Nature 385:347-350, 1997.
  • Flore O, Rafii S, Ely J, O'Leary JO, Hyjek EM, Cesarman E. Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus. Nature 394, 588-592, 1998.
  • Cesarman E. Kaposi's sarcoma-associated herpesvirus--the high cost of viral survival. N Engl J Med, 349:1107-1109,2003.
  • Guasparri I, Keller SA, Cesarman E. KSHV vFLIP is essential for the survival of infected lymphoma cells. J. Exp. Med. 199:993-1003, 2004.
  • Guasparri I, Bubman D, Cesarman E. EBV LMP2A mediated LMP1 signaling and survival of lymphoma cells through TRAF2 regulation. Blood, 111:3813-3820, 2008.
  • Di Bartolo D, Cannon M, Liu YF, Renne R, Chadburn A, Boshoff C, Cesarman E. Kaposi's sarcoma herpesvirus LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor. Blood, 111:4731-4740, 2008.
  • Chadburn A, Chiu A, Lee JY, Chen X, Hyjek E, Banham AH, Noy A, Kaplan LD, Sparano JA, Bhatia K, Cesarman E. Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium Clinical Trials 010 and 034. J Clin Oncology, 27:5039-48, 2009.
  • de Oliveira DE, Ballon G, Cesarman E. NF-kappaB signaling modulation by EBV and KSHV.& & Trends Microbiol. 18:248-57, 2010.
  •  Mesri MA, Cesarman E and Boshoff C.& Kaposi's sarcoma and its associated herpesvirus. Nature Reviews Cancer 10:707-19, 2010.
  • Krown SE, Dittmer DP, Cesarman E.& & Pilot Study of Oral Valganciclovir in Patients with Classic Kaposi Sarcoma. J. Infectious Diseases, 203:1082-6, 2011.
  • Ballon G, Chen K, Perez R, Tam W, and Cesarman E. Kaposi Sarcoma Herpesvirus (KSHV) vFLIP Induces B-cell Transdifferentiation and Tumorigenesis in Mice. J Clin Invest, 121:1141-1152, 2011.
  • Giulino L, Mathew S, Ballon G, Chadburn A, Barouk S, Antonicelli G, Leoncini L, Liu YF, Gogineni S, Tam W, Cesarman E. A20 (TNFAIP3) Genetic Alterations in EBV Associated AIDS Related Lymphoma. Blood,20:1114-1120, 2011.
  • Krown SE, Dittmer DP, Cesarman E.  Pilot Study of Oral Valganciclovir in Patients with Classic Kaposi Sarcoma. J. Infectious Diseases, 203:1082-6, 2011.
  • Mesri EA, Cesarman E. Kaposi's sarcoma herpesvirus oncogenesis is a Notch better in 3D. Cell Host Microbe10:529-31, 2011.
  •  Giulino Roth L, Wang K4, MacDonald TY, Mathew S, Tam Y, Cronin MT, Palmer G, Lucena-Silva N, Pedrosa F, Pedrosa M, Teruya-Feldstein J, Bhagat G, Alobeid B, Leoncini L, Bellan C, Rogena E, Pinkney KA, Rubin MA, Ribeiro RC, Yelensky R, Tam W, Stephens PJ, Cesarman E.  Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in anti-apoptotic and chromatin-remodeling genes. Blood, 120: 5181-4, 2012.
  • Mancuso M, Jiang L, Cesarman E, Erickson D. Multiplexed colorimetric detection of Kaposi's sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles. Nanoscale. 5:1678-86, 2013.
  • Levine AM, Noy A, Lee JY, Tam W, Ramos JC, Henry DH, Parekh S, Reid EG, Mitsuyasu R, Cooley T, Dezube BJ, Ratner L, Cesarman E, Tulpule A. Pegylated liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047. J Clin Oncol. 31:58-64, 2013.
  • Byun M, Ma CS, Akçay A, Pedergnana V, Palendira U, Myoung J, Avery DT, Liu Y, Abhyankar A, Lorenzo L, Schmidt M, Lim HK, Cassar O, Migaud M, Rozenberg F, Canpolat N, Aydogan G, Fleckenstein B, Bustamante J, Picard C, Gessain A, Jouanguy E, Cesarman E, Olivier M, Gros P, Abel L, Croft M, Tangye SG, Casanova JL: Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med 210:1743-59, 2013.

  • Wong LY, Brulois K, Toth Z, Inn KS, Lee SH, O'Brien K, Lee H, Gao SJ, Cesarman E, Ensser A, Jung JU: The product of KSHV K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol 87:12069-79, 2013.
  • Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T , Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E: Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood 122:2837-47, 2013.
  • Damania B, Cesarman E: Chapter 65: Kaposi’s sarcoma-associated herpesvirus. In: Fields Virology. 6th Edition. Knipe DM and Howley PH (Eds). Lippincott Williams & Wilkins.  2080-2128, 2013.
  • Giulino-Roth L, Cesarman E: Molecular biology of Burkitt lymphoma. In: Burkitt’s Lymphoma. Robertson ES (Ed). Springer, New York, 2013.
  • Said J, Cesarman E, Knowles DM: Lymphadenopathy and the lymphoid neoplasms associated with HIV infection and other causes of immunosuppression. In: Knowles’ Neoplastic Hematopathology. 3rd Ed. Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.
  • Wang, YL, Cesarman E, Knowles DM: Antigen receptor genes: Structure, function, and molecular analysis in clinical applications. In: Knowles’ Neoplastic Hematopathology. 3rd Ed Orazi A, Weiss L, Foucar K, Knowles DM (Eds). Lippincott Williams and Wilkins, Philadelphia, 2013.
  • Cesarman E: Pathology of lymphoma in HIV. Curr Opinion Oncol 25:487-494, 2013.
  • Cesarman, E. Gammaherpesvirus and lymphoprolliferative disorders. Annu Rev Pathol, 9:349-72, 2014.
  • Jiang L, Mancuso M, Lu Z, Akar G, Cesarman E and Erickson D.  Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics. Scientific Reports. In Press.


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