Bhupesh Parashar, M.D.

Radiation Oncology

Publications

Selected Publications

Samuel Trichter, Albert Sabbas, Mary Katherine Hayes, Bhupesh Parashar, Fridon Kulidzhanov, Lucy Nedialkova, Dattatreyudu Nori. Treatment planning, quality assurance and treatment delivery using mammosite: Pittfalls and Remedies. Presented at American Brachytherapy Society (ABS) suppl, May 2008 (in Press)

Bhupesh Parashar, Albert Sabbas, Dattatreyudu Nori. Should Seminal Vesicles be included in high dose clinical target volume in Radiation treatment of Prostate Cancer? ACRO Suppl, February 2008 (in Press)

Alina Hirsh, Bhupesh Parashar, Samuel Trichter, Albert Sabbas, Dattatreyudu Nori. Initial PSA response and toxicity after Cs-131 prostate brachytherapy: A single institution experience, American Brachytherapy Society (Submitted)

Bhupesh Parashar, Roger Kereztes, Dattatreyudu Nori. Concomitant chemotherapy and radiation pose a significant risk of symptomatic pneumonitis in the management of locally advanced lung cancer. Int J Radiat Oncol Biol Phys. Suppl October 2007. (#2581)

Bhupesh Parashar, Ravindra Yaparpalvi, Madhur Garg, Shalom Kalnicki, Jonathan J Beitler. Tolerance of cervical spinal cord to HDR Brachytherapy and external beam radiation in treatment of head and neck cancers. Brachytherapy. Suppl 4. 79-120, 2005. Abstract P-51

Melissa Krupski, Sai Latha Shankar, Kathy O’Guin, Bhupesh Parashar, Chidi Okwuaka and Bridget Shafit Zagardo. UCN-01 is a Chk kinase inhibitor that results in apoptotic cell death in neuroblastomas. Presented at AECOM Department of Pathology Retreat, June 2003.

Bhupesh Parashar, Sai Latha Shankar, James Butler and Bridget Shafit-Zagardo. Inhibition of human neuroblastoma cell growth by CAY10404, a selective Cox-2 inhibitor. Presented at AECOM Department of Pathology Retreat, June 2003. Abstract

Bhupesh Parashar, Sai Shankar and Bridget Shafit-Zagardo. XIAP levels are increased after x-irradiation in the neuroblastoma cell line MSN. Presented at AECOM Department of Pathology Retreat, June 2002. Abstract

MH Einstein, Bhupesh Parashar, B Sood, N Goldman, GL Goldberg, CD Runowicz, PS Anderson, AL Fields. Long-term complications of concomitant chemoradiotherapy for locally advanced cervical cancer. Presented at American Society of Clinical Oncology, March 2002. Abstract 2526

Mark Einstein, Bhupesh Parashar, Brij Sood, Noah Goldman, Gary Goldberg, Carolyn Runowicz, Patrick Anderson, Abbie Fields. Long-term complications of concomitant chemoradiotherapy for locally advanced cervical cancer. Society of Gynecologic Oncologists Proceedings 2002. Abstract 139

Jennifer Brown, Bhupesh Parashar, Anupam Singh, Elazar Rabbani, Dean Engelhardt, Namita Roy- Chowdhury and Jayanta Roy-Chowdhury. Oral tolerization to Hepatitis B virus proteins

Ameliorates hepatic inflammation in Tupaia carrying Hepatitis B viral infection. Hepatology. Suppl 2000.Abstract 934

Jennifer Brown, Bhupesh Parashar, Anupam Singh, Elazar Rabbani, Dean Engelhardt, Namita Roy- Chowdhury and Jayanta Roy-Chowdhury. Progressive repopulation of the liver by human hepatocytes, transplanted into immune-deficient mice. Hepatology. 2000. Abstract 644

Bhupesh Parashar, Namita Roy-Chowdhury, Bhadrasain Vikram, Niloy J Deb, Anupam Singh, Jayanta Roy-Chowdhury and Chandan Guha. Preparative hepatic irradiation and triiodothyronine (T3) therapy for massive liver repopulation by transplanted normal hepatocytes: amelioration of jaundice in Gunn rats. Hepatology. Suppl 2000. Abstract 173

Guha C, Parashar B, Roy-Chowdhury N, Gorla GR, Deb NJ, Sharma A, Alfieri A, Gupta S, Roy- Chowdhury J, and Vikram B. Hepatocyte transplantation ameliorates radiation-induced liver damage and increases survival after partial hepatic resection and irradiation. Int J Radiat Oncol Biol Phys. 46(3). Institute for Clinical and Translational Research (ICTR) 2000 Proceedings: Abstract 107

A Kadakol, SS Ghosh, B Parashar, N Roy-Chowdhury and J Roy-Chowdhury. Gene transfer to the liver using recombinant viral vectors. Indian Journal of Gastroenterology. December 1999. Abstract

A Kadakol, SS Ghosh, B Parashar, N Roy-Chowdhury and J Roy-Chowdhury. Molecular mechanisms of inherited disorders of bilirubin glucuronidation. Indian Journal of Gastroenterology. December 1999. Abstract

Betsy T Kren, Bhupesh Parashar, Paramita Bandyopadhyay, Namita Roy-Chowdhury, Jayanta Roy- Chowdhury and Clifford J Steer. Site-specific modification of single nucleotides in liver genomic DNA. Presented at International Symposium on Innovative Therapies and 6th International Symposium on Mucopolysaccharidosis and Related Diseases (ISIT MPS), Minneapolis, Minnesota. Abstract 44

JJ Brown, B Parashar, DL Engelhardt, G Nuovo, E Rabbani and J Roy-Chowdhury. Oral tolerization therapy for hepatitis B virus infection in Tupaia belangeri. Presented at Meeting on Antiviral Therapy, Third International Conference on Therapies for Viral Hepatitis, Maui, Hawaii; Abstract 75:27

JJ Brown, B Parashar, A Kadakol, BS Sepal, N Roy-Chowdhury. Murine models for infection and replication of Human Hepatitis B generated by transplantation of human hepatocytes. Universita degli studi di Cagliari, October 8, 1999. Abstract 12

B Parashar, M Takahashi, J Brown, N Roy-Chowdhury, J Roy-Chowdhury. Hepatocyte transplantation: status and remaining hurdles at the turn of the century. Presented at Universita degli studi di Cagliari, 8-9. October 8, 1999. Abstract 8-9

C Guha, B Parashar, N Roy-Chowdhury, GR Gorla, NJ Deb, A Alfieri, B Vikram, J Roy-Chowdhury. Complete, long-term normalization of serum bilirubin levels in Gunn rats after Hepatocyte transplantation following partial hepatectomy and liver irradiation. Hepatology Suppl 30(4): Pt. 2, October 1999. Abstract 108

JJ Brown, B Parashar, A Goyal, A Kadakol, D Engelhardt, E Rabbani, N Roy-Chowdhury, J Roy Chowdhury. Primary human hepatocytes, transplanted into the liver of Rag-2-deficient mice, retain differentiated function and can host Hepatitis B virus infection. Hepatology. 1 Suppl 30(4): Pt. 2. October 1999. Abstract 618

B Parashar, K Ramani, A Kadakol, N Roy-Chowdhury, DP Sarkar and J Roy-Chowdhury. Efficient liver-targeted gene delivery in vivo into UDP-glucoronosyltransferase-deficient Gunn rats using the F-protein of the hemolytic virus of Japan. Hepatology. 30(4): Pt. 2, October 1999. Abstract 723

S Lee, M Takahashi, Y Kawashita, SS Ghosh, B Parashar, A Kadakol, N Roy-Chowdhury and J Roy- Chowdhury. Liver-directed gene therapy: 2000 and beyond. Presented at Falk Symposia, Basel, Switzerland, October 20, 1999. Abstract 114-116

Guha C, Parashar B, Roy-Chowdhury N, Gorla GR, Deb NJ, Sharma A, Alfieri A, Gupta S, Roy- Chowdhury J, Vikram B. Hepatic irradiation as a preparative regimen for hepatocyte transplantation. Int J Radiat Oncol Biol Phys. Suppl 45(3), 1999. Abstract 338

B Parashar, S Ghosh, A Kadakol, BV Sauter, M Takahashi, N Roy-Chowdhury, J Milano, D Strayer and Jayanta Roy-Chowdhury. Recombinant Simian virus 40 vectors integrate into the host genome, and permit efficient, long-term and repeatable gene transfer to the liver in vivo. Hepatology. Suppl 30 (4): Pt. 2, October 1999. Abstract 551

A Kadakol, SS Ghosh, B Parashar, N Roy-Chowdhury and J Roy-Chowdhury. Gene transfer to the liver using recombinant viral vectors. Presented at Sixth European Meeting on Hepatocarcinogenesis. Vienna, Austria, September 1999. Abstract

N Roy-Chowdhury, CJ Steer, B Kren, B Parashar, J Roy-Chowdhury. Oligonucleotide-mediated site-directed gene repair therapy. Presented at American Society of Gene Therapy Meeting, Denver, Colorado, 1999. Abstract

S Ghosh, A Kadakol, B Parashar, NR Thummala, N Roy-Chowdhury, J Roy-Chowdhury. Liver- directed gene therapy: status at the turn of the century. Presented at Meeting on Genetic and Immune Mediated Diseases of the Biliary Tree, Courmayeur Congress Center, Italian Biliary Club, Italy, March 1999. Abstract

M Takahashi, B Parashar, N Roy-Chowdhury, J Roy-Chowdhury. Prospects of hepatocyte transplantation at the turn of the century. Presented at Institute for Frontier Medical Sciences, Tokyo, Japan, 1999. Abstract

B Parashar, A Kadakol, N Roy-Chowdhury, J Roy-Chowdhury. Site-specific gene conversion in vivo. Presented at Albert Einstein Comprehensive Cancer Center Retreat. Jan 24-25, 1999. Abstract

Ira J Fox, Stephen C. Strom, Bernhard V Sauter, Bhupesh Parashar, J Roy-Chowdhury. Treatment of Crigler-Najjar syndrome by transplantation of allogenic hepatocytes. Einstein Quarterly, 15 (3): 166-167, 1998. Abstract

Bhupesh Parashar, Ajith Kadakol, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury. Targets and strategies for liver-directed gene therapy. The Keio Journal of Medicine. June 1998. Abstract 114

B Parashar, BV Sauter, N Roy-Chowdhury, A Kadakol, J Milano, D Strayer and Jayanta Roy-Chowdhury. Gene transfer to the liver in vivo using replication-deficient recombinant SV40 vectors results in long-term amelioration of jaundice in Gunn rats. Hepatology Suppl 28, 1998, 4. Abstract 1364

JJ Brown, B Parashar, E Rabbani, D Engelhardt, H Moshage, N Roy-Chowdhury, J Roy-Chowdhury. The Mouse-human chimeric organ HBV animal model for infection and replication of Hepatitis Virus B in vivo. Gastroenterology. 1998:114. Abstract: L0073

JJ Brown, B Parashar, A Kadakol, E Rabbani, D Engelhardt, J Roy-Chowdhury. Serological and patho-morphological characterization of Human Hepatitis B virus in a small primate Tupaia belangeri. Hepatology. Suppl 1998; 28, 4. Abstract 937

BT Kren, P Bandyopadhyay, B Parashar, N Roy-Chowdhury, J Roy-Chowdhury, and CJ Steer. Site-specific correction of genetic diseases in liver resulting from single nucleotide mutations in genomic DNA. Hepatology. Suppl 1998: 28, 4. Abstract 1344

Jonathan J Beitler, Bhupesh Parashar, Ravindra Yaparpalvi. Tolerance of Cervical Spinal Cord to Brachytherapy and External Beam Radiation for Head and Neck Cancers. (submitted)

Bhupesh Parashar1, M.D, Dattatreyudu Nori1, M.D., Brij Saxena2* PhD. Gene and Cell Therapy for Prostate Cancer Advances in Gene, Molecular and Cell Therapy. 1: 80-88, June 2007.

Bhupesh Parashar, Bridget Shafit-Zagardo. Inhibition of human Neuroblastoma in SCID mice by low-dose of selective Cox-2 inhibitor nimesulide. Journal of Neuro-oncology. (online March 2006) 78(2):129-134, June 2006.

Bhupesh Parashar, Sai Latha Shankar, Kathy O’Guin, James Butler, Bhadrasain Vikram and Bridget Shafit-Zagardo. Inhibition of human Neuroblastoma cell growth by the Cox-2 inhibitor CAY10404. Journal of Neuro-oncology. 71(2):141-148, January 2005.

Sai L. Shankar, Melissa Krupski, Bhupesh Parashar, Chidi Owaku, Kathy O’Guin, Sridhar Mani and Bridget Shafit-Zagardo. UCN-01 induces apoptotic cell death in six independent human Neuroblastoma cell lines via Akt inhibition and GSK3β activation. Journal of Neurochemistry. 90(3):702-711, August 2004.

Bhaskar Mukherjee, PhD, Hui Zhao, PhD, Bhupesh Parashar, MD, Brij M Sood, MD, Panna S Mahadevia, MD, Harold P Klinger, MD, PhD, Bhadrasain Vikram, MD, Mohan P Achary, PhD. Microsatellite dinucleotide (T-G) repeat: a candidate DNA marker for breast metastasis. Cancer Detection and Prevention. 27(1):19-23, January 2003.

David S Strayer, Francisco Branco, MA Zern, Priscilla Yam, Sandra A Calarota, Carmen N Nichols, John Zaia, John Rossi, Haiting Li, Bhupesh Parashar, SS Ghosh and J Roy-Chowdhury. Durability of transgene expression and vector integration: recombinant SV40-derived gene therapy vectors. Molecular Therapy. Vol 6(2):227-237, August 2002.

Chandan Guha, Bhupesh Parashar, Niloy J Deb, Madhur Garg, Giridhar R Gorla, Anupam Singh, Namita Roy-Chowdhury, Bhadrasain Vikram and Jayanta Roy-Chowdhury. Long-term normalization of serum bilirubin levels by massive repopulation of Gunn rat liver by normal hepatocytes, transplanted after preparative hepatic irradiation and partial hepatectomy. Hepatology. 36(2):354- 362, 2002.

Jennifer Brown, Bhupesh Parashar, Edwin Ouyang, Namita Roy-Chowdhury, George Y Wu and Jayanta Roy-Chowdhury. Hepatitis B and C; Carrier to Cancer: Gene therapy for Hepatitis B: Strategies and Animal Models. Sarin SK and Okuda K (eds). Harcourt Publishing, 147-161, 2002.

Namita Roy-Chowdhury, Ajit Kadakol, Marsha Caton, Sung W Lee, Yujo Kawashita, Bhupesh Parashar, Siddhartha S. Ghosh, Baljit S. Sappal, Jayanta Roy-Chowdhury. Cell and Gene Therapies for Metabolic Liver Diseases: Inherited Jaundice as a Model. Summary Report of a Symposium: Genes and Gene Delivery for Diseases of Alcoholism. Alcoholism: Clinical & Experimental Research. II.B.3. 25(12):1778-1800, December 2001.

Chandan Guha, Bhupesh Parashar, Niloy J Deb, Anand Sharma, Giridhar R Gorla, Alan Alfieri, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury and Bhadrasain Vikram. Liver irradiation: a potential preparative regimen for hepatocyte transplantation. Int J Radiat Oncol Biol Phys. 2001 Feb 1: 49(2): 451-457.

Bhupesh Parashar, Namita Roy-Chowdhury and Jayanta Roy-Chowdhury. Hepatocyte Transplantation. UpToDate. 2000.

Jennifer J Brown, Bhupesh Parashar, Han Moshage, Kathryn E Tanaka, Dean Engelhardt, Elazar Rabbani, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury. A long-term Hepatitis B Viremia model generated by transplanting non-tumorigenic immortalized Human Hepatocytes in Rag-2 deficient mice. Hepatology. 31(1): 173-181, 2000.

Bernhard V Sauter and Bhupesh Parashar et al. Long-term correction of bilirubin glucuronidation in the bilirubin-UDP-glucoronosyltransferase-deficient Gunn rat by in vivo gene therapy with recombinant SV40. Gastroenterology. 2000; 119:1348-1357.

Siddhartha S Ghosh, Masahiko Takahashi, Narsing R Thummala, Bhupesh Parashar, Namita Roy-Chowdhury and Jayanta Roy-Chowdhury. Liver-directed gene therapy: promises and prospects at the turn of the century. Journal of Hepatology. Suppl 1 2000; 32: 238-252.

Bhupesh Parashar, Sung Lee, Siddhartha S Ghosh, Yujo Kawashita, Narsing R Thummala, Masahiko Takahashi, Namita Roy-Chowdhury and Jayanta Roy-Chowdhury. Comparison of currently existing methods of gene transfer to the liver and prospects of liver-directed gene therapy. Gastroenterology Today. 2000; 4:28-33.

Kadakol A, Takahashi M, Parashar B, Guha C, Ghosh SS, Roy-Chowdhury N and Roy-Chowdhury J. Hepatocyte transplantation at the turn of the century: prospects and remaining hurdles. Transplantation Today. 1999.

Betsy T Kren, Bhupesh Parashar, Paramita Bandyopadhyay, Namita Roy-Chowdhury, Jayanta Roy- Chowdhury, and Clifford J Steer. Correction of the UDP-glucoronosyltransferase gene defect in the Gunn rat model of Crigler-Najjar syndrome type 1. Proceedings of National Academy of Sciences. August 31, 1999, 10349-10354.

Ajith Kadakol, Masahiko Takahashi, Bhupesh Parashar, Chandan Guha, Siddhartha S Ghosh, Namita Roy-Chowdhury and Jayanta Roy-Chowdhury. Hepatocyte transplantation at the turn of the century: prospects and remaining hurdles. J Organ Biology. 6 (4): 43-51, 1999.

Namita Roy-Chowdhury, Peter J Bosma, Bhupesh Parashar, Harminder Singh, Peter LM Jansen, Jayanta Roy-Chowdhury. Cholestatic liver diseases: Crigler-Najjar Syndrome: Molecular Basis and Prospects for Gene Therapy. MP Manns, JL Boyer, PLM Jansen, J Reichen (eds). Kluwer Academic Publishers, London. 1998: 203-214.

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