Publications
Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M.V. and Parada, L.F. 1991. The TRK Proto-Oncogene is a Receptor for Nerve Growth Factor. Science 252:554-558.
Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and M.V. Chao. 1991. High Affinity NGF Binding Requires Co-expression of the TRK Proto-Oncogene and the Low Affinity NGF Receptor. Nature 350:678-683.
Donovan, M.J., Hahn, R., Tessarollo, L. and Hempstead, B.L. 1996. Neurotrophin-3 is required for mammalian cardiac development:identification of an essential nonneuronal neurotrophin function. Nature Genetics 14: 210-213.
Donovan, M.J., Lin, M.I., Wiegn, P., Ringsted, R., Kraemer, R., Hahn, R., Wang, S., Ibanez, C., Rafii, S., Hempstead, B.L. 2000. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization, Development, 127:4531-4540.
Lee, R., Kermani, P., Teng, K., Hempstead, B.L. 2001. The pro-NGF precursor dictates pro-apoptotic or pro-survival outcomes through differential receptor binding. Science 294: 1945-1948
Beattie, M.S., Harrington, A.W., Lee, R., Kim, J.Y., Boyce, S.L., Longo, F.M., Breshnahan, J.C., Hempstead, B.L. and Yoon, S.O 2002 Pro-NGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 36, 375-86.
Harrington, AW, Leiner B, Blechschmitt C, Arevalo, JC, Lee R, MorlK, Meyer M, Hempstead BL. Yoon SO, Giehl KM. 2004. Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc Natl Acad Sci 101:2742- 2749.
Kermani, P, Rafii, D, Jin DK, Whitlock P, Schwarz W, Chiang, Vincent L, Friedrich M, Shido K, Hackett NR, Crystal RG, Rafii, S, Hempstead BL. 2005 Neurotrophins promote revascularization by local recruitment of TrkB endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest 115: 653-663.
Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, Jacobsen C., Kliemannel M, Schwarz E, Willnow TE, Hempstead BL, Petersen CM. 2004. A novel neurotrophin receptor essential for proNGF induced neuronal cell death. Nature, 427: 843-848.
Pang, PMW, Teng H, Teng, KK, Cheng, S. Zaitsev E, Sakata K, Yung WH, Hempstead BL, Lu B. 2005. Proteolytic conversion from pro-to-mature BDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science, 306:487-91.
Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B. 2005. Activation of p75(NTR) by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience. 8:1069-77.
Kermani, P, Rafii D, Jin DK, Whitlock P, Schaffer W, Chiang A, Vincent L, Friedrich M, Shido K, Hackett NR, Crystal RG, Raffi S, Hempstead BL 2005. Neurotrophins promote revascularization by local recruitment of TrkB endothelial cells and systemic mobilization of hematopoietic progenitors. J.Clin Invest 115:653-63. With Commentary. J. Clin Invest 115:596-598.
Kraemer R, Baker PJ, Kent KCm Ye Y, Han JJ, Tejada R, Silane M, Upmacis R, Deeb R, Chen Y, Levine DM, Hempstead B. 2005 Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoproteinE-null mutant mouse. Circulation 112-3644-53.
Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS. 2006 Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science. 314:140-3.
Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A. 2007. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci.
Yang J, Siao CJ, Nagappan G, Marinic T, Jing D, McGrath K, Chen ZY, Mark W, Tessarollo L, Lee FS, Lu B, Hempstead BL. 2009. Nat Neurosci.
Nagappan G, Zaitsev E, Senatorov VV Jr, Yang J, Hempstead BL, Lu B. 2009. Control of extracellular cleavage of ProBDNF by high frequency neuronal activity.Proc Natl Acad Sci
