Andrew I. Schafer, M.D.

Hematology/Oncology

Publications

Christodoulides N, Durante W, Kroll MH, Schafer AI. Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide. Circulation. 1995; 91:2306–2309.

Kroll MH, Hellums JD, McIntire LV, Schafer AI, Moake JL. Platelets and shear stress. Blood. 1996; 88:1525–1541.

Wagner CT, Durante W, Christodoulides N, Hellums JD, Schafer AI. Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells. J Clin Invest. 1997; 100:589–596.


Durante W, Liao L, Reyna S, Peyton KJ, Schafer AI. Physiological cyclic stretch directs L-arginine transport and metabolism to collagen synthesis in vascular smooth muscle cells. FASEB J. 2000; 14: 1775-1783.

Chapman GB, Durante W, Hellums JD, Schafer AI. Physiological cyclic stretch causes cell cycle arrest in cultured vascular smooth muscle cells. Am J Physiol. 2000; 278:H748–754.

Peyton KJ, Reyna SV, Chapman GB, Ensenat D, Liu XM, Wang H, Schafer AI, Durante W. Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth. Blood 2002;99:4443-4448.

Wang H, Jieng XH, Chapman G, Durante W, Sibinga N, Schafer AI. Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Blood. 2002; 99:939-945.

Loscalzo J, Schafer AI, ed. THROMBOSIS AND HEMORRHAGE, 3rd edition. Lippincott Williams & Wilkins, Philadelphia, 2003; 1142 pp.

Schafer AI. Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia. Blood 2006; 107:4214-4222.

Hasan RN, Schafer AI. Hemin upregulates Egr-1 expression in vascular smooth muscle cells via ROS, ERK1/2 and Elk-1. Circ Res 2008; 102: 42-50.

Jamaluddin MS, Chen I, Yang F, Jiang XH, Jan M, Liu X, Schafer AI, Durante W, Yang XF, Wang H. Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood 2007; 110: 3648-3655.

Keswani AN, Peyton KJ, Durante W, Schafer AI, Tulis DA. The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects. J Cardiovascular Pharmacol Ther. 2009: 14:116-124.

Zhang DQ, Jiang X, Fang P, Yan Y, Song J, Gupta S, Schafer AI, Durante W, Kruger WD, Yang X, Wang H. Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine β-synthase deficient mice. Circulation. 2009; 120: 1893-1902.

Schafer AI, ed. THE VANISHING PHYSICIAN-SCIENTIST? Ithaca and London: Cornell University Press, 2009.

Chen NC, Yang F, Capecci LM, Gu Z, Schafer AI, Durante W, Yang XF, Wang H. Regulation of homocysteine metabolism and methylation in human and mouse tissues. FASEB J. 2010;24:2804-2817.

Santisakultarn TP, Cornelius NR, Nishimura N, Schafer AI, Sliver RT, Doerschuk PC, Olbricht WL, Schaffer CB. In vivo two-photon excited fluorescence microscopy reveals cardiac and respiration-dependent pulsatile blood flow in cortical blood vessels in mice. Am J Physiol 2012; 302:H1367-H1377.

Cheng ZJ, Jiang XH, Kruger WD, Pratico D, Gupta S, Mallilankaraman K, Madesh M, Schafer AI, Durante W, Yang X, and Wang H, Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta-synthase-deficient mice. Blood 2011; 118:1998-2006.

Goldman L, Schafer AI, eds. CECIL MEDICINE, 24th edition. Philadelphia: Saunders Elsevier, 2011.

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