Guillain-Barré syndrome is a neurological disorder in which the body's immune system attacks part of the peripheral nervous system. The onset can be quite sudden and unexpected. The disorder can develop over a few days, or it may take up to several weeks. A person experiences the greatest weakness within the first two weeks after symptoms appear.

Who is affected by Guillain-Barré syndrome?

Although rare, afflicting about one person in 100,000, Guillain-Barré syndrome can affect people at any age and both men and women equally. The disorder usually occurs a few days or weeks after a person has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, pregnancy, surgery, or vaccinations will trigger the syndrome.

Causes

Currently, it is not known why Guillain-Barré strikes some people. What is known is that the body's immune system begins to attack the body itself.

Normally, the cells of the immune system attack only foreign material and invading organisms, but in Guillain-Barré syndrome, the immune system starts to destroy the myelin sheath that surrounds the axons of many nerve cells, and, sometimes, the axons themselves.

When this occurs, the nerves cannot send signals efficiently, the muscles lose their ability to respond to the commands of the brain, and the brain receives fewer sensory signals from the rest of the body. The result is an inability to feel heat, pain, and other sensations.

Guillain-Barré syndrome can occur after a viral infection, surgery, trauma, or a reaction to an immunization.

Symptoms

The following are the most common symptoms of Guillain-Barré syndrome. However each individual may experience symptoms differently.

The first symptoms include varying degrees of weakness or tingling sensations in the legs, which, sometimes, spreads to the arms and upper body. The symptoms may increase in severity until the following does or does not occur - in these cases, the disorder is considered a medical emergency:

• Muscles cannot be used at all
• The patient becomes nearly paralyzed
• It may become difficult to breathe
• Blood pressure and heart rate are affected

Although symptoms can become life threatening, partial recovery is possible from even the most severe cases of Guillain-Barré syndrome. However, some degree of weakness may still be present.

The symptoms of Guillain-Barré syndrome may resemble other medical conditions or problems. Always consult your physician for a diagnosis.

Diagnosis

According to the National Institute of Neurological Disorders and Stroke (NINDS):
Guillain-Barré is called a syndrome rather than a disease because it is not clear that a specific disease-causing agent is involved. A syndrome is a medical condition characterized by a collection of symptoms (what the patient feels) and signs (what a physician can observe or measure). The signs and symptoms of the syndrome can be quite varied, so physicians may, on rare occasions, find it difficult to diagnose Guillain-Barré in its earliest stages.

Signs and symptoms that may differentiate Guillain-Barré from other disorders include the following. With Guillain-Barré:

• Symptoms appear on both sides of the body.
• Symptoms appear quickly - days or weeks as opposed to months.
• Reflexes are usually lost.
• Cerebral spinal fluid that bathes the spinal cord and brain contains more protein than usual.

Other diagnostic procedures include the following:

• Spinal tap (Also called a lumbar puncture.) - a special needle is placed into the lower back, into the spinal canal. This is the area around the spinal cord. The pressure in the spinal canal and brain can then be measured. A small amount of cerebral spinal fluid (CSF) can be removed and sent for testing to determine if there is an infection or other problems. CSF is the fluid that bathes the brain and spinal cord.
• Electrodiagnostic tests (i.e., electromyography (EMG) and nerve conduction velocity, or NCV) - studies that evaluate and diagnose disorders of the muscles and motor neurons. Electrodes are inserted into the muscle, or placed on the skin overlying a muscle or muscle group, and electrical activity and muscle response are recorded.

Treatment for Guillain-Barré:

Specific treatment for Guillain-Barré syndrome will be determined by your physician based on:

• Your age, overall health, and medical history
• Extent of the syndrome
• Your tolerance for specific medications, procedures, or therapies
• Expectations for the course of the syndrome
• Your opinion or preference

Currently, there is no known cure for Guillain-Barré syndrome. However, the goal of the treatment plan is to lessen the severity of the illness and to assist in the recovery. Treatment may include:

• High-dose immunoglobin therapy - involves proteins being administered by intravenous injections to attack invading organisms.
• Hormonal therapy
• Physical therapy (to increase muscle flexibility and strength)
• Plasmapheresis - process in which whole blood is removed from the body, and the red and white blood cells are separated from the plasma and are returned to the body

Through research, new treatments for Guillain-Barré syndrome are continually being identified.