Anne Moscona, M.D.

Publications

Selected:

•Moscona A. Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory disease. The Journal of Clinical Investigation 115: 1688-1698, 2005.

•Moscona A. Neuraminidase inhibitors for influenza. New England Journal of Medicine 353:1363-1373, 2005.

•Moscona A. Oseltamivir resistance – Disabling our influenza defenses. New England Journal of Medicine 353: 2633-2636, Dec 22, 2005.

•Porotto M, Doctor L, Carta P, Fornabaio M, Greengard O, Kellogg GE, Moscona A. Inhibition of Hendra virus fusion. Journal of Virology 80 (19): 9837-9849, 2006.

•Porotto M, Fornabaio M, Kellogg GE, Moscona A. A second receptor binding site on human parainfluenza virus type 3 hemagglutinin-neuraminidase contributes to activation of the fusion mechanism. Journal of Virology 81(7): 3216-28, 2007.

•Palermo LM, Porotto M, Greengard O, and Moscona, A. Fusion promotion by a paramyxovirus hemagglutinin-neuraminidase protein: pH modulation of receptor avidity of binding sites I and II by pH. Journal of Virology 81 (17), 9152-9161, 2007.

•Porotto M, Orefice G, Yokoyama C, Mungall B, Realubit R, Sganga M, Aljofan M, Whitt M, Glickman F, and Moscona A. Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy. Journal of Virology May; 83(10):5148-55, 2009. Epub 2009 Mar 4.

•Moscona A. Global Transmission of Oseltamivir-Resistant Influenza. New England Journal of Medicine Mar 5; 360(10):953-6, 2009.

•Moscona A, Porotto M, Palmer S, Tai C, Aschenbrenner L, Triana-Baltzer G, Li H, Wurtman D, Niewiesk S, Fang F.. A recombinant sialidase fusion protein effectively inhibits human parainfluenza viral infection in vitro and in vivo. Journal of Infectious Diseases 202 (2): 234-241, 2010.

•Porotto M, Yokoyama C, Palermo LM, Mungall B, Aljofan M, Cortese R, Pessi A, and Moscona A. Viral entry inhibitors targeted to the membrane site of action. Journal of Virology 84 (13): 6760-6768, 2010.

•Porotto M, Rockx B, Yokoyama CC, Talekar A, DeVito I, Palermo LM, Cortese R, Lu M, Feldmann H, Pessi A, Moscona A. Inhibition of Nipah virus infection in vivo: Targeting an early stage of paramyxovirus fusion activation during viral entry. PLoS Pathogens 6 (10): e1001168. doi:10.1371/journal.ppat.1001168, 2010.

•Porotto M, Yi F, Moscona A*, LaVan DA* Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human viruses. PloS One 6(3): e16874. doi:10.1371/journal.pone.0016874. (*Co-corresponding authors), 2011

•Farzan, S, Palermo, LM., Yokoyama, CC., Orefice, G., Fornabaio, M., Sarkar, A., Kellogg, GE., Greengard, O., Porotto, M., and Moscona, A. Premature activation of the paramyxovirus fusion protein before target cell attachment: corruption of the viral fusion machinery. Journal of Biological Chemistry Nov 4;286(44):37945-54, 2011. Epub 2011 Jul 28.

•Porotto, M., DeVito, I., Palmer, S., Yee, J., Yokoyama, CC., Pessi, A., and Moscona, A. , Spring-loaded model revisited: Paramyxovirus fusion requires engagement of a receptor binding protein beyond initial triggering of the fusion protein. Journal of Virology Dec;85(24):12867-80, 2011. Epub 2011 Oct 5.

•Porotto M, Palmer S, Palermo L, and Moscona A. Mechanism of fusion triggering by paramyxoviruses: Communication between viral glycoproteins during entry. Journal of Biological Chemistry Jan 2;287(1):778-93, 2012. Epub 2011 Nov 22.

•Talekar A, Pessi A, Glickman F, Sengupta U, Briese T, Whitt MA, Mathieu C, Horvat B, Moscona A, Porotto M. Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment. PLoS One ;7(3):e30538, 2012. Epub 2012 Mar 2

•Porotto M, Salah Z, Devito I, Talekar A, Palmer SG, Xu R, Wilson IA, Moscona A. The second receptor binding site of the globular head of the Newcastle disease virus (NDV) hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion. J Virol. 2012 May;86(10):5730-41. Epub 2012 Mar 21.

•Palmer, S., Porotto, M., Palermo, L.M., Cunha, L., Greengard, O., Moscona, A. Adaptation of human parainfluenza virus to airway epithelium reveals fusion properties required for growth in host tissue. mBio. 2012 Jun 5;3(3). pii: e00137-12. doi: 10.1128/mBio.00137-12. Print 2012.

•Porotto M, Salah ZW, Gui L, Devito I, Jurgens EM, Lu H, Yokoyama CC, Palermo LM, Lee K, Moscona A. Regulation of paramyxovirus fusion activation: the hemagglutinin-neuraminidase protein stabilizes the fusion protein in a pre-triggered state. J Virol. 2012 Dec;86(23):12838-48. doi: 10.1128/JVI.01965-12. Epub 2012 Sep 19.

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